Ovaj gen kodira člana proteinske porodice ADAM (disintegrin i metaloproteinaza). Članovi ove porodice su membranski usidreni proteini strukturno srodni dezintegrinima zmijskog otrova, a uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj gen predstavlja kandidata za gen tumor supresora za rak dojke kod ljudi na osnovu svoje lokacije unutar minimalne regije hromosoma 17, sekvenca q21, prethodno definirane mapiranjem delecije tumora.[6]
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^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID8252040. S2CID11770397.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID15146197. S2CID27764390.
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