ADAM19
ADAM19 (MADDAM, meltrin beta) je gen integrina A i M metaloproteinaze 19.[5]
Aminokiselinska sekvenca
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPGGAGAARL | CLLAFALQPL | RPRAAREPGW | TRGSEEGSPK | LQHELIIPQW | ||||
| KTSESPVREK | HPLKAELRVM | AEGRELILDL | EKNEQLFAPS | YTETHYTSSG | ||||
| NPQTTTRKLE | DHCFYHGTVR | ETELSSVTLS | TCRGIRGLIT | VSSNLSYVIE | ||||
| PLPDSKGQHL | IYRSEHLKPP | PGNCGFEHSK | PTTRDWALQF | TQQTKKRPRR | ||||
| MKREDLNSMK | YVELYLVADY | LEFQKNRRDQ | DATKHKLIEI | ANYVDKFYRS | ||||
| LNIRIALVGL | EVWTHGNMCE | VSENPYSTLW | SFLSWRRKLL | AQKYHDNAQL | ||||
| ITGMSFHGTT | IGLAPLMAMC | SVYQSGGVNM | DHSENAIGVA | ATMAHEMGHN | ||||
| FGMTHDSADC | CSASAADGGC | IMAAATGHPF | PKVFNGCNRR | ELDRYLQSGG | ||||
| GMCLSNMPDT | RMLYGGRRCG | NGYLEDGEEC | DCGEEEECNN | PCCNASNCTL | ||||
| RPGAECAHGS | CCHQCKLLAP | GTLCREQARQ | CDLPEFCTGK | SPHCPTNFYQ | ||||
| MDGTPCEGGQ | AYCYNGMCLT | YQEQCQQLWG | PGARPAPDLC | FEKVNVAGDT | ||||
| FGNCGKDMNG | EHRKCNMRDA | KCGKIQCQSS | EARPLESNAV | PIDTTIIMNG | ||||
| RQIQCRGTHV | YRGPEEEGDM | LDPGLVMTGT | KCGYNHICFE | GQCRNTSFFE | ||||
| TEGCGKKCNG | HGVCNNNQNC | HCLPGWAPPF | CNTPGHGGSI | DSGPMPPESV | ||||
| GPVVAGVLVA | ILVLAVLMLM | YYCCRQNNKL | GQLKPSALPS | KLRQQFSCPF | ||||
| RVSQNSGTGH | ANPTFKLQTP | QGKRKVINTP | EILRKPSQPP | PRPPPDYLRG | ||||
| GSPPAPLPAH | LSRAARNSPG | PGSQIERTES | SRRPPPSRPI | PPAPNCIVSQ | ||||
| DFSRPRPPQK | ALPANPVPGR | RSLPRPGGAS | PLRPPGAGPQ | QSRPLAALAP | ||||
| KVSPREALKV | KAGTRGLQGG | RCRVEKTKQF | MLLVVWTELP | EQKPRAKHSC | ||||
| FLVPA |
Funkcija
Ovaj gen kodira člana porodice ADAM (domen dezintegrina i metaloproteinaze). Članovi ove porodice su proteini usidreni u membrani, strukturno srodni sa dezintegrinima zmijskog otrova, i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj član je transmembranski protein tipa I i služi kao marker za diferencijaciju dendritičnih ćelija. Također je dokazano da je aktivna metaloproteinaza, koja može biti uključena u normalne fiziološke i patološke procese kao što su migracija ćelija, adhezija ćelija, interakcije ćelija-ćelija i ćelija-matriks, te transdukcija signala. Alternativno splajsovanje rezultira dvije varijante transkripta.[5]
Interakcije
Pokazano je da ADAM19 inter-raguje sa ABI2.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135074 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000011256 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta)".
- ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting00000000000 with ADAM19 cytoplasmic tail". Molecular Biology Reports. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
Vanjski linkovi
- Lokacija ljudskog genoma ADAM19 i stranica sa detaljima o genu ADAM19 u UCSC Genome Browseru.
Dodatni izvori
- Adams MD, Kerlavage AR, Fields C, Venter JC (Jul 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nature Genetics. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434. S2CID 20528590.
- Inoue D, Reid M, Lum L, Krätzschmar J, Weskamp G, Myung YM, Baron R, Blobel CP (Feb 1998). "Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells". The Journal of Biological Chemistry. 273 (7): 4180–7. doi:10.1074/jbc.273.7.4180. PMID 9461614.
- Hirohata S, Seldin MF, Apte SS (Nov 1998). "Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11". Genomics. 54 (1): 178–9. doi:10.1006/geno.1998.5544. PMID 9806848.
- Fritsche J, Moser M, Faust S, Peuker A, Büttner R, Andreesen R, Kreutz M (Jul 2000). "Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation". Blood. 96 (2): 732–9. doi:10.1182/blood.V96.2.732. PMID 10887142.
- Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A (Mar 2001). "Roles of Meltrin beta /ADAM19 in the processing of neuregulin". The Journal of Biological Chemistry. 276 (12): 9352–8. doi:10.1074/jbc.M007913200. PMID 11116142.
- Wei P, Zhao YG, Zhuang L, Ruben S, Sang QX (Jan 2001). "Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta". Biochemical and Biophysical Research Communications. 280 (3): 744–55. Bibcode:2001BBRC..280..744W. doi:10.1006/bbrc.2000.4200. PMID 11162584.
- Zhao YG, Wei P, Sang QX (Nov 2001). "Inhibitory antibodies against endopeptidase activity of human adamalysin 19". Biochemical and Biophysical Research Communications. 289 (1): 288–94. Bibcode:2001BBRC..289..288Z. doi:10.1006/bbrc.2001.5958. PMID 11708814.
- Kang T, Zhao YG, Pei D, Sucic JF, Sang QX (Jul 2002). "Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites". The Journal of Biological Chemistry. 277 (28): 25583–91. doi:10.1074/jbc.M203532200. PMID 12006600.
- Díaz-Rodríguez E, Montero JC, Esparís-Ogando A, Yuste L, Pandiella A (Jun 2002). "Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding". Molecular Biology of the Cell. 13 (6): 2031–44. doi:10.1091/mbc.01-11-0561. PMC 117622. PMID 12058067.
- Kang T, Park HI, Suh Y, Zhao YG, Tschesche H, Sang QX (Dec 2002). "Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity". The Journal of Biological Chemistry. 277 (50): 48514–22. doi:10.1074/jbc.M208961200. PMID 12393862.
- Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
- Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA (maj 2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". The Journal of Biological Chemistry. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID 12615925.
- Chesneau V, Becherer JD, Zheng Y, Erdjument-Bromage H, Tempst P, Blobel CP (Jun 2003). "Catalytic properties of ADAM19". The Journal of Biological Chemistry. 278 (25): 22331–40. doi:10.1074/jbc.M302781200. PMID 12682046.
- Kang T, Tschesche H, Amy Sang QX (Aug 2004). "Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19". Experimental Cell Research. 298 (1): 285–95. doi:10.1016/j.yexcr.2004.04.022. PMID 15242783.
- Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M (Jul 2005). "Epigenetic regulation of the dendritic cell-marker gene ADAM19". Biochemical and Biophysical Research Communications. 332 (2): 456–64. Bibcode:2005BBRC..332..456E. doi:10.1016/j.bbrc.2005.04.149. PMID 15896713.
- Melenhorst WB, van den Heuvel MC, Stegeman CA, van der Leij J, Huitema S, van den Berg A, van Goor H (Jul 2006). "Upregulation of ADAM19 in chronic allograft nephropathy". American Journal of Transplantation. 6 (7): 1673–81. doi:10.1111/j.1600-6143.2006.01384.x. PMID 16827870. S2CID 24891674.
- Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura S (Jan 2007). "ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells". Biochemical and Biophysical Research Communications. 352 (1): 111–7. Bibcode:2007BBRC..352..111T. doi:10.1016/j.bbrc.2006.10.181. PMID 17112471.
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