JWH-138

JWH-138

Identifiers
IUPAC name (6aR,10aR)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-octyl-6H-Dibenzo[b,d]pyran-1-ol
CAS Number	431041-39-3
PubChem CID	102024084
Chemical and physical data
Formula	C24H36O2
Molar mass	356.550 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC1=C2[C@]3([C@](C(C)(C)OC2=CC(CCCCCCCC)=C1)(CCC(C)=C3)[H])[H]
InChI InChI=InChI=1S/C24H36O2/c1-5-6-7-8-9-10-11-18-15-21(25)23-19-14-17(2)12-13-20(19)24(3,4)26-22(23)16-18/h14-16,19-20,25H,5-13H2,1-4H3/t19-,20-/m1/s1 Key:SFWRRSGOJSILSQ-WOJBJXKFSA-N

JWH-138 (THC-Octyl, Δ⁸-THC-C8) is a synthetic cannabinoid first synthesized by Roger Adams and studied heavily by John W. Huffman, with a K_i of 8.5nM at the CB₁ cannabinoid receptor.^[1] THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942.^[2]

The Δ³/Δ^6a(10a) isomer was synthesised in 1941, but was found to be slightly less active than Δ³-THC itself.^[3] The alternate isomer Δ⁹-THC-C8 has also been synthesised,^[4] and both the Δ⁸ and Δ⁹ isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl,^[5] but it is unclear if it has been identified as a natural product. Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion with THC-O-acetate which is commonly known as THC-O on packaging for grey market vaping liquids sold for use in humans.

• 1,2-Didehydro-3-oxo-THCO
• Cannabicyclohexanol
• Parahexyl
• Tetrahydrocannabihexol
• THCP

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