JWH-150

JWH-150

Legal status
Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name (1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone
CAS Number	914458-18-7 Y
PubChem CID	44418303
ChemSpider	23277877 Y
CompTox Dashboard (EPA)	DTXSID701337047
Chemical and physical data
Formula	C25H23NO
Molar mass	353.465 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCN1C=C(C=C1C2=CC=CC=C2)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C25H23NO/c1-2-3-16-26-18-21(17-24(26)20-11-5-4-6-12-20)25(27)23-15-9-13-19-10-7-8-14-22(19)23/h4-15,17-18H,2-3,16H2,1H3   Y Key:PTIAQHRJOQEMCO-UHFFFAOYSA-N  Y

JWH-150 ((1-butyl-5-phenylpyrrol-3-yl)-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 60 ± 1nM) and CB₂ (K_i = 15 ± 2nM) receptors, with a moderate four-fold selectivity for the CB₂ receptor. JWH-150 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.^[1]

In the United States JWH-150 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-150.^[2][3][4][5]

In Canada, JWH-150 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.^{[citation needed]}

In the United Kingdom, JWH-150 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.^{[citation needed]}

• List of JWH cannabinoids
• Synthetic cannabinoid

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