DPF2
Protein cinkovog prsta ubi-d4 je protein koji je kosd ljudi koodiran genom DPF2.[5][6]
Protein kodiran ovim genom član je porodice domena d4, karakteriziran strukturnim motivom sličnim cinkovim prstima. Ovaj protein funkcionira kao transkripcijski faktor koji je neophodan za apoptotski odgovor nakon uskraćivanja faktora preživljavanja. Vjerojatno ima regulatornu ulogu u brzom hematopoetskim rastu i čelijskom prometu. Ovaj gen se smatra kandidatskim genom za multiplu endokrinu neoplaziju tip I, nasljedni kancerski sindrom koji uključuje višestruke paratiroidne, enteropankreasne i hipofizne tumore.[6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 391 aminokiselina, a molekulska težina 44.155 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAVVENVVK | LLGEQYYKDA | MEQCHNYNAR | LCAERSVRLP | FLDSQTGVAQ | ||||
| SNCYIWMEKR | HRGPGLASGQ | LYSYPARRWR | KKRRAHPPED | PRLSFPSIKP | ||||
| DTDQTLKKEG | LISQDGSSLE | ALLRTDPLEK | RGAPDPRVDD | DSLGEFPVTN | ||||
| SRARKRILEP | DDFLDDLDDE | DYEEDTPKRR | GKGKSKGKGV | GSARKKLDAS | ||||
| ILEDRDKPYA | CDICGKRYKN | RPGLSYHYAH | SHLAEEEGED | KEDSQPPTPV | ||||
| SQRSEEQKSK | KGPDGLALPN | NYCDFCLGDS | KINKKTGQPE | ELVSCSDCGR | ||||
| SGHPSCLQFT | PVMMAAVKTY | RWQCIECKCC | NICGTSENDD | QLLFCDDCDR | ||||
| GYHMYCLTPS | MSEPPEGSWS | CHLCLDLLKE | KASIYQNQNS | S |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000133884 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024826 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
- ^ a b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".
- ^ "UniProt, Q92785". Pristupljeno 21. 8. 2021.
Dopunska litertura
- Gabig TG, Mantel PL, Rosli R, Crean CD (1994). "Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells". J. Biol. Chem. 269 (47): 29515–9. doi:10.1016/S0021-9258(18)43910-5. PMID 7961935.
- Chestkov AV, Baka ID, Kost MV, et al. (1997). "The d4 gene family in the human genome". Genomics. 36 (1): 174–7. doi:10.1006/geno.1996.0440. PMID 8812431.
- Guru SC, Agarwal SK, Manickam P, et al. (1997). "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
- Gabig TG, Crean CD, Klenk A, et al. (1998). "Expression and chromosomal localization of the Requiem gene". Mamm. Genome. 9 (8): 660–5. doi:10.1007/s003359900840. PMID 9680388. S2CID 22559464.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Vanjski linkovi
- DPF2 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
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