HES3

HES3
Identifikatori
AliasiHES3
Vanjski ID-jeviOMIM: 609971 MGI: 104877 HomoloGene: 7358 GeneCards: HES3
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za HES3
Genomska lokacija za HES3
Bend1p36.31Početak6,244,179 bp[1]
Kraj6,245,578 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za HES3
Genomska lokacija za HES3
Bend4 E2|4 83.01 cMPočetak152,370,429 bp[2]
Kraj152,376,119 bp[2]
Ontologija gena
Molekularna funkcija• vezivanje sa DNK
• transcription factor binding
• protein dimerization activity
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001106 transcription corepressor activity
• sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
Ćelijska komponenta• jedro
Biološki proces• hindbrain morphogenesis
• trochlear nerve development
• midbrain-hindbrain boundary morphogenesis
• GO:0045996 negative regulation of transcription, DNA-templated
• in utero embryonic development
• GO:1901227 negative regulation of transcription by RNA polymerase II
• GO:0009373 regulation of transcription, DNA-templated
• regulation of timing of neuron differentiation
• regulation of neurogenesis
• oculomotor nerve development
• transcription, DNA-templated
• midbrain development
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• neural tube development
• somitogenesis
• Notch signaling pathway
• Ćelijska diferencijacija
• anterior/posterior pattern specification
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

390992

15207

Ensembl

ENSG00000173673

ENSMUSG00000028946

UniProt

Q5TGS1

Q61657

RefSeq (mRNK)

NM_001024598

NM_008237

RefSeq (bjelančevina)

NP_001019769

NP_032263
NP_001390720
NP_001390721
NP_001390722
NP_001390723

Lokacija (UCSC)Chr 1: 6.24 – 6.25 MbChr 4: 152.37 – 152.38 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Transkripcijski faktor 3 Hes porodice bHLH jest protein koji je kod ljudi kodiran genom HES3 sa hromosoma 1.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 186 aminokiselina, a molekulska težina 19.968 Da.[6]

1020304050
MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQ
NSLQGLWPVPRGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAA
GSTMDSAGLGQEAPALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGS
SASVPPPQPASSRCAESPGLGLRVWRPWGSPGDDLN

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173673 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028946 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hes family bHLH transcription factor 3".
  6. ^ "UniProt, Q5TGS1" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

Šablon:Transkripcijski faktori i unutarćelijski receptori

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