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TAL1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2YPA, 2YPB
Identifikatori
Aliasi	TAL1
Vanjski ID-jevi	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	47,232,225 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	114,928,952 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • vezivanje sa DNK; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • histone deacetylase binding; • chromatin binding; • GO:0000975 transcription cis-regulatory region binding; • E-box binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein heterodimerization activity; • vezivanje enzima; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• histone deacetylase complex; • transcription regulator complex; • Lsd1/2 complex; • jedro; • nukleoplazma; • GO:0009327 makromolekulani kompleks;
Biološki proces	• megakaryocyte development; • megakaryocyte differentiation; • myeloid cell differentiation; • cell fate commitment; • Ćelijska diferencijacija; • GO:0009373 regulation of transcription, DNA-templated; • regulation of mast cell differentiation; • spinal cord association neuron differentiation; • positive regulation of protein-containing complex assembly; • locomotory behavior; • positive regulation of erythrocyte differentiation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulation of stem cell population maintenance; • platelet formation; • positive regulation of mitotic cell cycle; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • generation of neurons; • basophil differentiation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • regulation of cell population proliferation; • hematopoietic stem cell differentiation; • astrocyte fate commitment; • Angiogeneza; • neuron differentiation; • embryonic hemopoiesis; • erythrocyte differentiation; • definitive hemopoiesis; • regulation of myeloid cell differentiation; • positive regulation of cell division; • hemangioblast cell differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • erythrocyte maturation; • regulation of hematopoietic stem cell differentiation; • Hematopoeza; • transcription by RNA polymerase II; • negative regulation of erythrocyte differentiation; • positive regulation of protein tyrosine kinase activity; • positive regulation of signaling receptor activity;
	Izvori:Amigo / QuickGO
Ortolozi
	6886
	21349
	ENSG00000162367
	ENSMUSG00000028717
	P17542
	P22091
NM_001287347; NM_001290403; NM_001290404; NM_001290405; NM_001290406;
	NM_003189
	NM_011527; NM_001287388
NP_001274276; NP_001277332; NP_001277333; NP_001277334; NP_001277335;
	NP_003180
	NP_001274317; NP_035657
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 T-ćelijske akutne limfocistne leukemije (tj. TAL1, također zvana leukemija matičnih ćelija/akutna leukemija T-ćelija 1 (tj. SCL/TAL1]) jest protein koji je kod ljudi kodiran genom TAL1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 331 aminokiselina, a molekulska težina 34.271 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTERPPSEAA	RSDPQLEGRD	AAEASMAPPH	LVLLNGVAKE	TSRAAAAEPP
VIELGARGGP	GGGPAGGGGA	ARDLKGRDAA	TAEARHRVPT	TELCRPPGPA
PAPAPASVTA	ELPGDGRMVQ	LSPPALAAPA	APGRALLYSL	SQPLASLGSG
FFGEPDAFPM	FTTNNRVKRR	PSPYEMEITD	GPHTKVVRRI	FTNSRERWRQ
QNVNGAFAEL	RKLIPTHPPD	KKLSKNEILR	LAMKYINFLA	KLLNDQEEEG
TQRAKTGKDP	VVGAGGGGGG	GGGGAPPDDL	LQDVLSPNSS	CGSSLDGAAS
PDSYTEEPAP	KHTARSLHPA	MLPAADGAGP	R

Funkcija

Protein koji kodira TAL1 je transkripcijski faktor zvani bazni heliks-petkja-heliks.

Interakcije

Pokazalo se da je TAL1 u interakcijama sa:

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162367 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028717 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (august 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. Bibcode:1989PNAS...86.5039F. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
^ "UniProt, P17542" (jezik: en.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ ^a ^b ^c ^d ^e Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (januar 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
^ Huang S, Qiu Y, Stein RW, Brandt SJ (septembar 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
^ ^a ^b Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (oktobar 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
^ ^a ^b Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (august 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
^ ^a ^b Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (oktobar 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
^ Huang S, Brandt SJ (mart 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
^ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (oktobar 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
^ Hsu HL, Wadman I, Baer R (april 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

Dopunska literatura

Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013.
Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia". Blood. 79 (5): 1327–33. doi:10.1182/blood.V79.5.1327.1327. PMID 1311214.
Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation". EMBO J. 11 (11): 4073–81. doi:10.1002/j.1460-2075.1992.tb05500.x. PMC 556917. PMID 1396592.
Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene". Oncogene. 6 (8): 1477–88. PMID 1886719.
Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias". Genes Chromosomes Cancer. 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581. S2CID 2464453.
Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650.
Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus". Mol. Cell. Biol. 10 (12): 6426–35. doi:10.1128/mcb.10.12.6426. PMC 362919. PMID 2247063.
Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC 551682. PMID 2303035.
Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361.
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues". Blood. 85 (3): 675–84. doi:10.1182/blood.V85.3.675.bloodjournal853675. PMID 7833471.
Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line". Oncogene. 9 (10): 3013–6. PMID 8084606.
Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen". Oncogene. 8 (11): 3043–6. PMID 8414504.
Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1". Mol. Cell. Biol. 13 (2): 801–8. doi:10.1128/mcb.13.2.801. PMC 358963. PMID 8423803.

Vanjski linkovi

TAL1 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162367 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028717 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2740341-5] Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (august 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. Bibcode:1989PNAS...86.5039F. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.

[entrez-6] "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".

[UniProt-7] "UniProt, P17542" (jezik: en.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid16407974-8] Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (januar 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.

[pmid10490830-9] Huang S, Qiu Y, Stein RW, Brandt SJ (septembar 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.

[pmid7568177-10] Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (oktobar 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.

[pmid8078932-11] Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (august 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.

[pmid7957052-12] Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (oktobar 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.

[pmid10688671-13] Huang S, Brandt SJ (mart 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.

[pmid12239153-14] Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (oktobar 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.

[pmid8159721-15] Hsu HL, Wadman I, Baer R (april 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

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TAL1