Serotonin

Serotonin
Formula rangka serotonin
Data klinikal
Nama lain5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin
Data fisiologi
Sumber tisuNukleus rafe, sel enterokromafin
Tisu sasaranSeluruh sistem
Reseptor5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7
AgonisTak terus: SSRI, MAOI
Pelopor5-HTP
BiosintesisDekarboksilase asid L-amino aromatik
MetabolismeMAO
Pengecam
  • 3-(2-Aminoetil)-1H-indola-5-ol
Nombor CAS
PubChem CID
IUPHAR/BPS
ChemSpider
KEGG
Ligan PDB
CompTox Dashboard (EPA)
ECHA InfoCard100.000.054 Sunting ini di Wikidata
Serotonin
Model bola-dan-batang molekul serotonin
Model bola-dan-batang molekul serotonin
Nama
Nama IUPAC
5-Hidroksitriptamina
Nama IUPAC pilihan
3-(2-Aminoetil)-1H-indol-5-ol
Nama lain
5-HT, 5-Hidroksitriptamina, Enteramina, Trombositin, 3-(β-Aminoetil)-5-hidroksiindol, Trombotonin
Pengecam
Imej model 3D Jmol
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.000.054
KEGG
MeSH Serotonin
UNII
  • InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 ☑Y
    Key: QZAYGJVTTNCVMB-UHFFFAOYSA-N ☑Y
  • InChI=1/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
    Key: QZAYGJVTTNCVMB-UHFFFAOYAX
  • C1=CC2=C(C=C1O)C(=CN2)CCN
Sifat
C10H12N2O
Jisim molar 176.215 g/mol
Rupa bentuk Serbuk putih
Takat lebur 167.7 °C (333.9 °F; 440.8 K) 121–122 °C (ligroin)[3]
Takat didih 416 ± 30 °C (pada 760 Torr)[1]
Sedikit larut
Keasidan (pKa) 10.16 dalam air pada 23.5 °C[2]
Momen dwikutub 2.98 D
Bahaya
MSDS External MSDS
Dos maut (LD) atau kepekatan dos maut (LC)
LD50 (median dos)
 750 mg/kg (subkutaneus, tikus),[4] 4500 mg/kg (intraperitoneal, tikus),[5] 60 mg/kg (oral, tikus)
Kecuali jika dinyatakan sebaliknya, data diberikan untuk bahan-bahan dalam keadaan piawainya (pada 25 °C [77 °F], 100 kPa).
 ☑Y pengesahan (apa yang perlu: ☑Y/N?)
Rujukan kotak info

Serotonin (5-hidroksitriptamina; 5-HT) ialah suatu pengutus saraf monoamino yang disintesiskan pada neuron-neuron serotonergis dalam sistem saraf pusat dan sel-sel enterokromafin dalam saluran pencernaan. Hormon ini dipercaya sebagai pemberi perasaan selesa dan senang.[6]

Rujukan

  1. ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994–2011 ACD/Labs)
  2. ^ Mazák K, Dóczy V, Kökösi J, Noszál B (April 2009). "Proton speciation and microspeciation of serotonin and 5-hydroxytryptophan". Chemistry & Biodiversity. 6 (4): 578–590. doi:10.1002/cbdv.200800087. PMID 19353542. S2CID 20543931.
  3. ^ Pietra S (1958). "[Indolic derivatives. II. A new way to synthesize serotonin]". Il Farmaco; Edizione Scientifica (dalam bahasa Itali). 13 (1): 75–79. PMID 13524273.
  4. ^ Erspamer V (1952). "Ricerche preliminari sulle indolalchilamine e sulle fenilalchilamine degli estratti di pelle di Anfibio". Ricerca Scientifica. 22: 694–702.
  5. ^ Tammisto T (1967). "Increased toxicity of 5-hydroxytryptamine by ethanol in rats and mice". Annales Medicinae Experimentalis et Biologiae Fenniae. 46 (3): 382–384. PMID 5734241.
  6. ^ Young SN (2007). "How to increase serotonin in the human brain without drugs". Rev. Psychiatr. Neurosci. 32 (6): 394–99. PMID 18043762.

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