Protein-coding gene in the species Homo sapiens
T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene .[ 5] [ 6]
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor .
Interactions
TAL1 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000162367 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028717 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma" . Proc Natl Acad Sci U S A . 86 (13): 5039– 43. Bibcode :1989PNAS...86.5039F . doi :10.1073/pnas.86.13.5039 PMC 297552 PMID 2740341 . ^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1" .^ a b c d e Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis" . EMBO J . 25 (2): 357– 66. doi :10.1038/sj.emboj.7600934 . PMC 1383517 PMID 16407974 . ^ Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein" . Oncogene . 18 (35): 4958– 67. doi :10.1038/sj.onc.1202889 PMID 10490830 . ^ a b Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1" . Proc. Natl. Acad. Sci. U.S.A . 92 (21): 9585– 9. Bibcode :1995PNAS...92.9585O . doi :10.1073/pnas.92.21.9585 PMC 40846 PMID 7568177 . ^ a b Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (18): 8617– 21. Bibcode :1994PNAS...91.8617V . doi :10.1073/pnas.91.18.8617 PMC 44657 PMID 8078932 . ^ a b Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831– 9. doi :10.1002/j.1460-2075.1994.tb06809.x . PMC 395422 PMID 7957052 . ^ Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor" . Mol. Cell. Biol . 20 (6): 2248– 59. doi :10.1128/mcb.20.6.2248-2259.2000 . PMC 110841 PMID 10688671 . ^ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1" . Blood . 100 (7): 2430– 40. doi :10.1182/blood-2002-02-0568 PMID 12239153 . ^ Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (8): 3181– 5. Bibcode :1994PNAS...91.3181H . doi :10.1073/pnas.91.8.3181 PMC 43539 PMID 8159721 .
Further reading
Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning . 10 (5): 269– 76. doi :10.1002/stem.5530100504 . PMID 1453013 . Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia" . Blood . 79 (5): 1327– 33. doi :10.1182/blood.V79.5.1327.1327 PMID 1311214 . Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation" . EMBO J . 11 (11): 4073– 81. doi :10.1002/j.1460-2075.1992.tb05500.x . PMC 556917 PMID 1396592 . Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein" . Blood . 80 (11): 2858– 66. doi :10.1182/blood.V80.11.2858.bloodjournal80112858 PMID 1450410 . Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene". Oncogene . 6 (8): 1477– 88. PMID 1886719 . Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias". Genes Chromosomes Cancer . 1 (3): 194– 208. doi :10.1002/gcc.2870010303 . PMID 1964581 . S2CID 2464453 . Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia" . J. Exp. Med . 172 (5): 1403– 8. doi :10.1084/jem.172.5.1403 . PMC 2188666 PMID 2230650 . Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus" . Mol. Cell. Biol . 10 (12): 6426– 35. doi :10.1128/mcb.10.12.6426 . PMC 362919 PMID 2247063 . Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein" . EMBO J . 9 (2): 415– 24. doi :10.1002/j.1460-2075.1990.tb08126.x . PMC 551682 PMID 2303035 . Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif" . Proc. Natl. Acad. Sci. U.S.A . 86 (24): 10128– 32. doi :10.1073/pnas.86.24.10128 PMC 298658 PMID 2602361 . Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1" . Proc. Natl. Acad. Sci. U.S.A . 92 (21): 9585– 9. Bibcode :1995PNAS...92.9585O . doi :10.1073/pnas.92.21.9585 PMC 40846 PMID 7568177 . Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues" . Blood . 85 (3): 675– 84. doi :10.1182/blood.V85.3.675.bloodjournal853675 PMID 7833471 . Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831– 9. doi :10.1002/j.1460-2075.1994.tb06809.x . PMC 395422 PMID 7957052 . Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (18): 8617– 21. Bibcode :1994PNAS...91.8617V . doi :10.1073/pnas.91.18.8617 PMC 44657 PMID 8078932 . Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line". Oncogene . 9 (10): 3013– 6. PMID 8084606 . Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (8): 3181– 5. Bibcode :1994PNAS...91.3181H . doi :10.1073/pnas.91.8.3181 PMC 43539 PMID 8159721 . Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen". Oncogene . 8 (11): 3043– 6. PMID 8414504 . Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1" . Mol. Cell. Biol . 13 (2): 801– 8. doi :10.1128/mcb.13.2.801 . PMC 358963 PMID 8423803 .
External links
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
