en SOX15

SOX15
Identifiers
Aliases	SOX15, SOX20, SOX26, SOX27, SRY-box 15, SRY-box transcription factor 15
External IDs	OMIM: 601297; MGI: 98363; HomoloGene: 74586; GeneCards: SOX15; OMA:SOX15 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,590,094 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,547,553 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; skin of abdomen; ; skin of leg; ; mucosa of pharynx; ; vagina; ; right hemisphere of cerebellum; ; olfactory zone of nasal mucosa; ; gonad; ; epithelium of esophagus;
	Top expressed in
	morula; ; blastocyst; ; morula; ; corneal stroma; ; transitional epithelium of urinary bladder; ; lip; ; secondary oocyte; ; zygote; ; esophagus; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; chromatin binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of myoblast proliferation; cell differentiation; male gonad development; regulation of transcription, DNA-templated; positive regulation of satellite cell activation involved in skeletal muscle regeneration; negative regulation of striated muscle tissue development; regulation of transcription by RNA polymerase II; positive regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; chromatin organization; myoblast development; skeletal muscle tissue regeneration; positive regulation of transcription by RNA polymerase II; central nervous system development; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6665
	20670
	ENSG00000129194
	ENSMUSG00000041287
	O60248
	P43267
	NM_006942
	NM_009235
	NP_008873
	NP_033261
	Wikidata
View/Edit Human	View/Edit Mouse

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.^[5]^[6]^[7]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129194 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041287 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.
^ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.
^ ^a ^b "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20". Biochim. Biophys. Acta. 1396 (2): 132–7. doi:10.1016/s0167-4781(97)00186-3. PMID 9540826.
Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Lett. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568. S2CID 551497.
Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene". Mamm. Genome. 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678. S2CID 792477.
Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11". Gene. 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129194 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041287 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978787-5] Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.

[pmid9730625-6] Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.

[entrez-7] "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Agama	Bahasa	Biografi	Budaya	Ekonomi	Elektronika
Film	Filsafat	Geografi	Indonesia	Ilmu	Lingkungan
Masyarakat	Matematika	Militer	Mitologi	Musik	Olahraga
Pendidikan	Politik	Sastra	Sejarah	Seni	Teknologi

SOX15

See also

References

Further reading

Portal di Ensiklopedia Dunia