Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDAgene.[3][4][5]
Function
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[5]
Dawson MJ, Trapani JA, Briggs RC, Nicholl JK, Sutherland GR, Baker E (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID7806273. S2CID12788123.
Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J (February 1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". Journal of Cellular Biochemistry. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID8175894. S2CID37002803.
Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". Journal of Cellular Biochemistry. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID12112016. S2CID30240885.
Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M (December 2003). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID14618084. S2CID1868558.
Briggs RC, Atkinson JB, Miranda RN (May 2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". Journal of Cellular Biochemistry. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID15778972. S2CID39863400.
