en MEOX2

MEOX2
Identifiers
Aliases	MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs	OMIM: 600535; MGI: 103219; HomoloGene: 4330; GeneCards: MEOX2; OMA:MEOX2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	15,686,683 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	37,229,533 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; parietal pleura; ; spinal ganglia; ; tibial nerve; ; synovial joint; ; subcutaneous adipose tissue; ; tendon of biceps brachii; ; saphenous vein; ; sural nerve; ; trigeminal ganglion;
	Top expressed in
	left lung lobe; ; sciatic nerve; ; lumbar spinal ganglion; ; dermis; ; hand; ; foot; ; ankle; ; human fetus; ; carotid body; ; limb bud;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleus;
Biological process	neuron death; roof of mouth development; regulation of transcription, DNA-templated; somite specification; blood circulation; transcription, DNA-templated; limb development; multicellular organism development; angiogenesis; skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; negative regulation of cell migration involved in sprouting angiogenesis; transcription by RNA polymerase II; somite development;
	Sources:Amigo / QuickGO
Orthologs
	4223
	17286
	ENSG00000106511
	ENSMUSG00000036144
	P50222
	P32443
	NM_005924
	NM_008584
	NP_005915
	NP_032610
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.^[5]^[6]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.^[6] MEOX2 has been implicated in the initiation of tumors in glioma.^[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.^[8]^[9]

Interactions

MEOX2 has been shown to interact with PAX1^[10] and PAX3.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID 7713505.
^ ^a ^b "Entrez Gene: MEOX2 mesenchyme homeobox 2".
^ Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC 9016080. PMID 35436995.
^ Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC 5620156. PMID 28978016.
^ Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.
^ ^a ^b Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

External links

MEOX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106511 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036144 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7713505-5] LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID 7713505.

[entrez-6] "Entrez Gene: MEOX2 mesenchyme homeobox 2".

[7] Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC 9016080. PMID 35436995.

[8] Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC 5620156. PMID 28978016.

[9] Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.

[pmid11423130-10] Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. S2CID 40668112.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

MEOX2

Function

Interactions

References

Further reading

External links