en Interleukin 1 receptor, type I

IL1R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G0Y, 1IRA, 1ITB, 4DEP, 4GAF
Identifiers
Aliases	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDs	OMIM: 147810; MGI: 96545; HomoloGene: 677; GeneCards: IL1R1; OMA:IL1R1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,179,874 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,317,257 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; tibia; ; pericardium; ; corpus epididymis; ; decidua; ; caput epididymis; ; urethra; ; vena cava; ; visceral pleura; ; parietal pleura;
	Top expressed in
	islet of Langerhans; ; seminal vesicula; ; umbilical cord; ; skin of external ear; ; medullary collecting duct; ; aortic valve; ; primary oocyte; ; ciliary body; ; tunica media of zone of aorta; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type I, activating receptor activity; signal transducer activity; platelet-derived growth factor receptor binding; protease binding; protein binding; transmembrane signaling receptor activity; interleukin-1 receptor activity; interleukin-1 binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; external side of plasma membrane;
Biological process	cell surface receptor signaling pathway; immune response; regulation of inflammatory response; signal transduction; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; response to interleukin-1; cytokine-mediated signaling pathway; interleukin-1-mediated signaling pathway; positive regulation of interferon-gamma production; positive regulation of T-helper 1 cell cytokine production; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	3554
	16177
	ENSG00000115594
	ENSMUSG00000026072
	P14778
	P13504
NM_000877; NM_001288706; NM_001320978; NM_001320980; NM_001320981;
	NM_001320982; NM_001320983; NM_001320984; NM_001320985; NM_001320986
	NM_001123382; NM_008362
NP_000868; NP_001275635; NP_001307907; NP_001307909; NP_001307910;
	NP_001307911; NP_001307912; NP_001307913; NP_001307914; NP_001307915
	NP_001116854; NP_032388
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.^[5]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[5]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,^[6] Myd88^[7]^[8] and IL1RAP.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026072 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
^ Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
^ Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343). UNITED STATES: 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

External links

IL1R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115594 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026072 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL1R1 interleukin 1 receptor, type I".

[pmid9360994-6] Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.

[pmid10854325-7] Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.

[pmid9374458-8] Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343). UNITED STATES: 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.

[pmid9371760-9] Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

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Interleukin 1 receptor, type I

Interactions

See also

References

Further reading

External links

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