en CD79B

CD79B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KG5
Identifiers
Aliases	CD79B, AGM6, B29, IGB, CD79b molecule, Igbeta
External IDs	OMIM: 147245; MGI: 96431; HomoloGene: 521; GeneCards: CD79B; OMA:CD79B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,932,336 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,205,588 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; lymph node; ; appendix; ; apex of heart; ; blood; ; monocyte; ; gonad; ; bone marrow; ; anterior pituitary;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; blood; ; bone marrow; ; granulocyte; ; submandibular gland; ; thymus; ; subcutaneous adipose tissue; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; protein homodimerization activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; integral component of plasma membrane; extracellular exosome; membrane; nucleoplasm; external side of plasma membrane; B cell receptor complex; cytoplasm; cytosol;
Biological process	cell surface receptor signaling pathway; adaptive immune response; immune response; signal transduction; immune system process; B cell differentiation; B cell receptor signaling pathway; protein homooligomerization; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	974
	15985
	ENSG00000007312
	ENSMUSG00000040592
	P40259
	P15530
	NM_000626; NM_001039933; NM_021602; NM_001329050
	NM_008339; NM_001313939
	NP_000617; NP_001035022; NP_001315979; NP_067613
	NP_001300868; NP_032365
	Wikidata
View/Edit Human	View/Edit Mouse

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.^[5]

It is associated with agammaglobulinemia-6.

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

Reth M (1992). "Antigen receptors on B lymphocytes". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.
Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761. S2CID 23910309.
Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031. S2CID 25093082.
Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.
Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45". J. Biol. Chem. 269 (25): 17238–44. doi:10.1016/S0021-9258(17)32545-0. PMID 7516335.
Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.
Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMC 2192043. PMID 7539038.
Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol. Lett. 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.
Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.
Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.
Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism". Immunogenetics. 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081. S2CID 6966566.
Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes". J. Immunol. 153 (6): 2369–80. doi:10.4049/jimmunol.153.6.2369. PMID 8077654. S2CID 22158525.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491–8. doi:10.4049/jimmunol.150.2.491. PMID 8419481. S2CID 36149482.
Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.
Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression". Blood. 87 (2): 666–73. doi:10.1182/blood.V87.2.666.bloodjournal872666. PMID 8555489.
Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia". Leukemia. 10 (5): 769–73. PMID 8656670.
Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.
Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". J. Immunol. 158 (7): 3062–9. doi:10.4049/jimmunol.158.7.3062. PMID 9120258. S2CID 20717278.

External links

CD79B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD79B genome location and CD79B gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human B-cell antigen receptor complex-associated protein beta chain (CD79B)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040592 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta".

[1]

[2]

[3]

[4]

[5]

Agama	Bahasa	Biografi	Budaya	Ekonomi	Elektronika
Film	Filsafat	Geografi	Indonesia	Ilmu	Lingkungan
Masyarakat	Matematika	Militer	Mitologi	Musik	Olahraga
Pendidikan	Politik	Sastra	Sejarah	Seni	Teknologi

CD79B

See also

References

Further reading

External links

Portal di Ensiklopedia Dunia