en CCR3 (gene)

CCR3
Identifiers
Aliases	CCR3, CC-CKR-3, CD193, CKR3, CMKBR3, C-C motif chemokine receptor 3, CKR 3, C C CKR3
External IDs	OMIM: 601268; MGI: 104616; HomoloGene: 20436; GeneCards: CCR3; OMA:CCR3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,266,706 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,831,726 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; blood; ; muscle of thigh; ; monocyte; ; gallbladder; ; appendix; ; gonad; ; muscle of arm; ; biceps brachii; ; granulocyte;
	Top expressed in
	embryo; ; spleen; ; granulocyte; ; zygote; ; intestinal villus; ; bone marrow; ; Ileal epithelium; ; secondary oocyte; ; blood; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; chemokine binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; cytoplasm; external side of plasma membrane;
Biological process	positive regulation of endothelial cell proliferation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; chemokine-mediated signaling pathway; positive regulation of angiogenesis; chemotaxis; cellular defense response; cell adhesion; inflammatory response; viral process; signal transduction; G protein-coupled receptor signaling pathway; immune response; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1232
	12771
	ENSG00000183625
	ENSMUSG00000035448
	P51677
	P51678
	NM_001164680; NM_001837; NM_178328; NM_178329
	NM_009914
	NP_001158152; NP_001828; NP_847898; NP_847899
	NP_034044
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.^[5]

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,^[6] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1, enabling viral infection in cells that also express CD4, the receptor of HIV-1.^[7] This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.^[5]

Interactions

CCR3 (gene) has been shown to interact with CCL5.^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035448 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CCR3 chemokine (C-C motif) receptor 3".
^ •Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.
^ Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, et al. (1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–1148. doi:10.1016/s0092-8674(00)81313-6. PMID 8674119.
^ Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
^ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d. PMID 11449371.

External links

"Chemokine Receptors: CCR3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2008-06-07. Retrieved 2008-11-25.
CCR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CCR3 genome location and CCR3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035448 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCR3 chemokine (C-C motif) receptor 3".

[6] •Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.

[7] Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, et al. (1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–1148. doi:10.1016/s0092-8674(00)81313-6. PMID 8674119.

[8] Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.

[pmid8642344-9] Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.

[pmid11449371-10] Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d. PMID 11449371.

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CCR3 (gene)

Function

See also

Interactions

References

Further reading

External links

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