en CD2

CD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Aliases	CD2, LFA-2, SRBC, T11, CD2 molecule
External IDs	OMIM: 186990; MGI: 88320; HomoloGene: 1338; GeneCards: CD2; OMA:CD2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	116,769,229 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	101,195,255 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; thymus; ; lymph node; ; testicle; ; appendix; ; blood; ; epithelium of nasopharynx; ; superficial temporal artery; ; spleen; ; mucosa of ileum;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; spleen; ; blood; ; right lung lobe; ; subcutaneous adipose tissue; ; embryo; ; ankle joint; ; embryo; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; signaling receptor binding; signaling receptor activity; antigen binding; protein kinase binding; receptor tyrosine kinase binding; protein self-association;
Cellular component	integral component of membrane; membrane; cell-cell junction; anchored component of plasma membrane; integral component of plasma membrane; extracellular region; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; plasma membrane; protein-containing complex; membrane raft;
Biological process	positive regulation of myeloid dendritic cell activation; heterotypic cell-cell adhesion; natural killer cell activation; membrane raft polarization; cell surface receptor signaling pathway; cell adhesion; positive regulation of tumor necrosis factor production; T cell activation; leukocyte migration; regulation of T cell differentiation; apoptotic process; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	914
	12481
	ENSG00000116824
	ENSMUSG00000027863
	P06729; Q53F96
	P08920
	NM_001767; NM_001328609
	NM_013486
	NP_001315538; NP_001758; NP_001758.2
	NP_038514
	Wikidata
View/Edit Human	View/Edit Mouse

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[6]

Function

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[7]

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.^[8]

Diagnostic relevance

CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.^[9]

Classification

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.^[8]

Interactions

CD2 has been shown to interact with CD2BP2,^[10] Lck^[11] and PSTPIP1.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027863 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A. 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.
^ Uniprot database entry for CD2 (accession number P06729)
^ Wilkins AL, Yang W, Yang JJ (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci. 4 (5): 367–73. doi:10.2174/1389203033487063. PMID 14529530.
^ ^a ^b Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci. 2 (1): 1–17. doi:10.2174/1389203013381251. PMID 12369898.
^ Leong, Anthony S-Y, Cooper, Kumarason, Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 61. ISBN 978-1-84110-100-2.
^ Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (December 1998). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14897–902. Bibcode:1998PNAS...9514897N. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
^ Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB (January 1996). "The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2". Journal of Experimental Medicine. 183 (1): 169–78. doi:10.1084/jem.183.1.169. PMC 2192399. PMID 8551220.
^ Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.

External links

CD2+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart
Human CD2 genome location and CD2 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A. 79 (23): 7489–93. Bibcode:1982PNAS...79.7489S. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.

[6] Uniprot database entry for CD2 (accession number P06729)

[7] Wilkins AL, Yang W, Yang JJ (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci. 4 (5): 367–73. doi:10.2174/1389203033487063. PMID 14529530.

[yang-8] Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci. 2 (1): 1–17. doi:10.2174/1389203013381251. PMID 12369898.

[Leong-9] Leong, Anthony S-Y, Cooper, Kumarason, Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 61. ISBN 978-1-84110-100-2.

[pmid9843987-10] Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (December 1998). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14897–902. Bibcode:1998PNAS...9514897N. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.

[pmid8551220-11] Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB (January 1996). "The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2". Journal of Experimental Medicine. 183 (1): 169–78. doi:10.1084/jem.183.1.169. PMC 2192399. PMID 8551220.

[pmid9857189-12] Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.

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CD2