CCL23

CCL23
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1G91

Identifikatori
AliasiCCL23
Vanjski ID-jeviOMIM: 602494 MGI: 98263 HomoloGene: 89167 GeneCards: CCL23
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za CCL23
Genomska lokacija za CCL23
Bend17q12Početak36,013,056 bp[1]
Kraj36,017,972 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za CCL23
Genomska lokacija za CCL23
Bend11 C|11 50.85 cMPočetak83,478,708 bp[2]
Kraj83,483,913 bp[2]
Ontologija gena
Molekularna funkcija• cytokine activity
• heparin binding
• chemokine activity
• CCR1 chemokine receptor binding
• CCR chemokine receptor binding
Ćelijska komponenta• extracellular region
• Vanćelijsko
Biološki proces• G protein-coupled receptor signaling pathway
• monocyte chemotaxis
• chemokine-mediated signaling pathway
• cell-cell signaling
• cellular response to tumor necrosis factor
• cellular calcium ion homeostasis
• neutrophil chemotaxis
• Hemotaksija
• negative regulation of C-C chemokine binding
• GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
• GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
• cellular response to interleukin-1
• positive regulation of ERK1 and ERK2 cascade
• cellular response to interferon-gamma
• lymphocyte chemotaxis
• GO:0072468 Transdukcija signala
• negative regulation of cell population proliferation
• inflammatory response
• regulation of signaling receptor activity
• eosinophil chemotaxis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

6368

20305

Ensembl

ENSG00000276114
ENSG00000274736

ENSMUSG00000018927

UniProt

P55773

P27784

RefSeq (mRNK)

NM_005064
NM_145898

NM_009139

RefSeq (bjelančevina)

NP_005055
NP_665905

NP_033165

Lokacija (UCSC)Chr 17: 36.01 – 36.02 MbChr 11: 83.48 – 83.48 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš
Hemokinski (C-C motivni) ligand 23
Identifikatori
SimbolCCL23
Alt. simboliSCYA23, Ckb-8, MPIF-1, MIP-3, CKb8
NCBI gen6368
HGNC10622
OMIM602494
PDB1G91
RefSeqNM_005064
UniProtP55773
Ostali podaci
LokusHrom. 17 q11.2
Pretraga za
StruktureSwiss-model
DomeneInterPro

Hemokinski (C-C motivni) ligand 23 (CCL23) je mali citokin koji pripadaju porodici CC hemokina, poznatoj i kao makrofagni upalni protein 3 (MIP-3) i mijeloidni progenitorski inhibitorni faktor 1 (MPIF-1). CCL23 se pretežno eksprimira u tkivima pluća i jetre , ali također i u koštanoj srži i posteljicama.[5] Eksprimira se i u nekim ćelijskim linijama mijeloidnog porijekla. CCL23 je vrlo hemotaktičan za mirovanje T-ćelija i monocita i blago hemotaktičan za neutrofile. Također se pripisuje inhibitornoj aktivnosti na prekursorima hematopoetskih ćelija.[5] Gen za CCL23 nalazi se na ljudskom hromosomu 17 u lokusu koji sadrži nekoliko drugih CC-hemokina. CCL23 je ligand za hemokinski receptor CCR1.[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 120 aminokiselina, a molekulska težina 13.411 Da[7].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin

L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

1020304050
MKVSVAALSCLMLVTALGSQARVTKDAETEFMMSKLPLENPVLLDRFHAT
SADCCISYTPRSIPCSLLESYFETNSECSKPGVIFLTKKGRRFCANPSDK
QVQVCVRMLKLDTRIKTRKN

Reference

  1. ^ a b c ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.
  6. ^ Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.
  7. ^ "UniProt, P55773". Pristupljeno 26. 6. 2021.

Vanjski linkovi

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