CCL3
Hemokinski (C-C motivni) ligand 3 (CCL3), znan i kao makrofagni upalni protein 1-alfa (MIP-1-alfa) je protein koji je kod ljudi kodiran genom CCL.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 92 aminokiseline, a molekulska težina 10.085 Da.[6].
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQVSTAALAV | LLCTMALCNQ | FSASLAADTP | TACCFSYTSR | QIPQNFIADY | ||||
| FETSSQCSKP | GVIFLTKRSR | QVCADPSEEW | VQKYVSDLEL | SA |
Funkcija
CCL3 je citokin koji pripada porodici CC hemokina koji su uključeni u akutno upalno stanje u regrutovanju i aktivaciji polimorfojedarnih leukocita[7] vezanjem na receptore CCR1, CCR4 i CCR5.[5]
Sherry et al. (1988) demonstrirali su dvije proteinske komponente MIP1, koje se nazivaju alfa (CCL3, ovaj protein) i beta (CCL4).[5][8]
CCL3 izaziva monofaznu groznicu brzog početka, čija je magnituda jednaka ili veća od groznice proizvedene bilo s rekombinantnim ljudskim faktorom nekroze tumora ili rekombinantnim ljudskim interleukinom-1. Međutim, za razliku od ova dva endogena pirogena, inhibitor ciklooksigenaza ibuprofen inhibitor ibuprofen ne može inhibirati groznicu izazvanu MIP-1, a CCL3 može učestvovati u upalnim odgovorom koji nije posredovan sintezom prostaglandina i klinički se ne može ablirati ciklooksigenazom.[9]
Interakcije
Pokazano je da CCL3 komunicira sa CCL4.[10] Privlači makrofage, monocite i neutrofile.
Također pogledajte
Reference
- ^ a b c ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000982 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
- ^ "UniProt, P10147". Pristupljeno 26. 6. 2021.
- ^ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
- ^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
- ^ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
- ^ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.
Dopunska literatura
- Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
- Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
- Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
- Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
Vanjski linkovi
- Lokacija ljudskog genoma CCL3 i stranica sa detaljima o genu CCL3 u UCSC Genome Browseru.
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