DOKUMEN123.COM

ITGB3
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
معین‌کننده‌ها
نام‌های دیگر	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
شناسه‌های بیرونی	OMIM: 173470; MGI: 96612; HomoloGene: 55444; GeneCards: ITGB3; OMA:ITGB3 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۱۷ (انسان)
پایان	47,313,743 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	104,561,302 bp
الگوی گسترش RNA
	بیشترین بیان در
	thoracic aorta; ; Descending thoracic aorta; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tendon of biceps brachii; ; tibial arteries;
	بیشترین بیان در
	endothelial cell of lymphatic vessel; ; superior surface of tongue; ; body of femur;
	داده‌های بیشتر بیان
	; ; ; ;
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	vascular endothelial growth factor receptor 2 binding; fibronectin binding; virus receptor activity; extracellular matrix binding; protein disulfide isomerase activity; protease binding; platelet-derived growth factor receptor binding; پیوند پروتئینی; identical protein binding; enzyme binding; cell adhesion molecule binding; neuregulin binding; coreceptor activity; fibroblast growth factor binding; insulin-like growth factor I binding; C-X3-C chemokine binding; integrin binding; fibrinogen binding;
ترکیبات سلولی	integral component of membrane; cell projection; alphav-beta3 integrin-vitronectin complex; membrane; focal adhesion; melanosome; receptor complex; پوسته یاخته; integral component of plasma membrane; ruffle membrane; cell surface; پیوند میان‌یاخته‌ای; integrin complex; platelet alpha granule membrane; integrin alphav-beta3 complex; اگزوزوم; lamellipodium membrane; هسته یاخته; microvillus membrane; filopodium membrane; alphav-beta3 integrin-IGF-1-IGF1R complex; alphav-beta3 integrin-PKCalpha complex; alphav-beta3 integrin-HMGB1 complex; glutamatergic synapse; سیناپس;
فرایند زیستی	negative regulation of lipoprotein metabolic process; apolipoprotein A-I-mediated signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein phosphorylation; regulation of cell migration; negative chemotaxis; positive regulation of endothelial cell proliferation; tube development; heterotypic cell-cell adhesion; angiogenesis involved in wound healing; بهبود زخم; platelet degranulation; انعقاد خون; extracellular matrix organization; smooth muscle cell migration; positive regulation of endothelial cell migration; رشد یاخته; cell-substrate adhesion; vascular endothelial growth factor receptor signaling pathway; چسبندگی سلولی; positive regulation of peptidyl-tyrosine phosphorylation; mesodermal cell differentiation; cell-substrate junction assembly; integrin-mediated signaling pathway; negative regulation of lipid storage; substrate adhesion-dependent cell spreading; negative regulation of lipid transport; cell-matrix adhesion; viral process; regulation of bone resorption; platelet aggregation; کوچ یاخته; negative regulation of macrophage derived foam cell differentiation; activation of protein kinase activity; leukocyte migration; cell adhesion mediated by integrin; platelet activation; apoptotic cell clearance; regulation of postsynaptic neurotransmitter receptor internalization; regulation of protein localization; regulation of serotonin uptake;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3690
	16416
	ENSG00000259207
	ENSMUSG00000020689
	P05106
	O54890
	NM_000212
	NM_016780
	NP_000203
	NP_058060
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعه تمایزی ۶۱ (انگلیسی: Cluster of differentiation 61) که با عنوانِ «اینتگرین بتا-۳» (ITGB3) هم شناخته می‌شود، نام پروتئینی است که در انسان توسط ژن «ITGB3» کُد می‌شود.^[۵]

این پروتئین بر سطح پلاکت‌ها یافت می‌شود^[۶] و نوعی «اینتگرین بتا ۳» است که در ترارسانی پیام و چسبندگی سلولی نقش دارد.^[۷]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000259207 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020689 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
↑ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. (2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. ISSN 1538-7933.
↑ "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".

مشارکت‌کنندگان ویکی‌پدیا. «CD61». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ دسامبر ۲۰۱۷.

بیشتر بخوانید

Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936: 340–54. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491.
Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.
Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.
Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem. 12 (1): 51–70. doi:10.2174/0929867053363522. PMID 15638730.
Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMC 1297263. PMID 16322781.