CD31
مجموعه تمایزی ۳۱ (انگلیسی: Cluster of Differentiation 31) یا بهاختصار «CD31» که با نامِ «ملکول چسبندگی سلول آندوتلیوم پلاکت» (PECAM-1) هم شناخته میشود، پروتئینی است که در انسان توسط ژن «PECAM1» کُد میشود و این ژن، بر روی کروموزوم ۱۷ واقع است.[۵][۶][۷][۸]
نقش مهم این ملکول، برداشتن نوتروفیلهای پیر از بدن است.
این پروتئین در سطح نوتروفیلها، پلاکتها، مونوسیتها، برخی انواع لنفوسیتهای تی و بخش بزرگی از اتصالات بینسلولیِ اندوتلیوم وجود دارد.
این مولکول همچنین در برخی از انواع سرطانها همچون تومورهای عروقی، اپیتلوئید همانژیواندتلیوما، تومورهای هیستولیتیک و پلاسماسیتوما بیان میشود. به ندرت ممکن است CD31 در برخی از انواع سارکومها (همچون سارکوم کاپوسی)[۹][۱۰] و کارسینوماها هم وجود داشته باشد.
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000261371 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000020717 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: platelet/endothelial cell adhesion molecule".
- ↑ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science. 247 (4947): 1219–22. doi:10.1126/science.1690453. PMID 1690453.
- ↑ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics. 34 (2): 229–32. doi:10.1006/geno.1996.0272. PMID 8661055.
- ↑ Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics. 37 (2): 226–8. doi:10.1006/geno.1996.0546. PMID 8921400.
- ↑ Ganjei-Azar, Parvin (2007). Color Atlas of Immunocytochemistry in Diagnostic Cytology. [New York]: Springer Science+Business Media, LLC. pp. 47. ISBN 978-0-387-32121-9.
- ↑ Paolo Gattuso, ed. (2010). Differential diagnosis in surgical pathology (2nd ed.). Philadelphia, PA: Saunders/Elsevier. pp. 108. ISBN 978-1-4160-4580-9.
- مشارکتکنندگان ویکیپدیا. «CD31». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۷ دسامبر ۲۰۱۷.
جستارهای وابسته
- Jackson DE (2003). "The unfolding tale of PECAM-1". FEBS Lett. 540 (1–3): 7–14. doi:10.1016/S0014-5793(03)00224-2. PMID 12681475.
- Newman PJ, Newman DK (2004). "Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology". Arterioscler. Thromb. Vasc. Biol. 23 (6): 953–64. doi:10.1161/01.ATV.0000071347.69358.D9. PMID 12689916.
- Ilan N, Madri JA (2004). "PECAM-1: old friend, new partners". Curr. Opin. Cell Biol. 15 (5): 515–24. doi:10.1016/S0955-0674(03)00100-5. PMID 14519385.
- Wong MX, Jackson DE (2004). "Regulation of B cell activation by PECAM-1: implications for the development of autoimmune disorders". Curr. Pharm. Des. 10 (2): 155–61. doi:10.2174/1381612043453504. PMID 14754395.
- Kalinowska A, Losy J (2007). "PECAM-1, a key player in neuroinflammation". Eur. J. Neurol. 13 (12): 1284–90. doi:10.1111/j.1468-1331.2006.01640.x. PMID 17116209.
- Stockinger H, Gadd SJ, Eher R, Majdic O, Schreiber W, Kasinrerk W, Strass B, Schnabl E, Knapp W (1991). "Molecular characterization and functional analysis of the leukocyte surface protein CD31". J. Immunol. 145 (11): 3889–97. PMID 1700999.
- Albelda SM, Muller WA, Buck CA, Newman PJ (1991). "Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule". J. Cell Biol. 114 (5): 1059–68. doi:10.1083/jcb.114.5.1059. PMC 2289123. PMID 1874786.
- Simmons DL, Walker C, Power C, Pigott R (1990). "Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen". J. Exp. Med. 171 (6): 2147–52. doi:10.1084/jem.171.6.2147. PMC 2187965. PMID 2351935.
- Kirschbaum NE, Gumina RJ, Newman PJ (1995). "Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain". Blood. 84 (12): 4028–37. PMID 7994021.
- Tang DG, Chen YQ, Newman PJ, Shi L, Gao X, Diglio CA, Honn KV (1993). "Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium". J. Biol. Chem. 268 (30): 22883–94. PMID 8226797.
- Behar E, Chao NJ, Hiraki DD, Krishnaswamy S, Brown BW, Zehnder JL, Grumet FC (1996). "Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease". N. Engl. J. Med. 334 (5): 286–91. doi:10.1056/NEJM199602013340502. PMID 8532023.
- Lu TT, Yan LG, Madri JA (1996). "Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11808–13. doi:10.1073/pnas.93.21.11808. PMC 38140. PMID 8876219.
- Almendro N, Bellón T, Rius C, Lastres P, Langa C, Corbí A, Bernabéu C (1997). "Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization". J. Immunol. 157 (12): 5411–21. PMID 8955189.
- Jackson DE, Ward CM, Wang R, Newman PJ (1997). "The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signaling". J. Biol. Chem. 272 (11): 6986–93. doi:10.1074/jbc.272.11.6986. PMID 9054388.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Famiglietti J, Sun J, DeLisser HM, Albelda SM (1997). "Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity". J. Cell Biol. 138 (6): 1425–35. doi:10.1083/jcb.138.6.1425. PMC 2132561. PMID 9298995.
- Deaglio S, Morra M, Mallone R, Ausiello CM, Prager E, Garbarino G, Dianzani U, Stockinger H, Malavasi F (1998). "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member". J. Immunol. 160 (1): 395–402. PMID 9551996.
- Coukos G, Makrigiannakis A, Amin K, Albelda SM, Coutifaris C (1999). "Platelet-endothelial cell adhesion molecule-1 is expressed by a subpopulation of human trophoblasts: a possible mechanism for trophoblast-endothelial interaction during haemochorial placentation". Mol. Hum. Reprod. 4 (4): 357–67. doi:10.1093/molehr/4.4.357. PMID 9620836.
- Cao MY, Huber M, Beauchemin N, Famiglietti J, Albelda SM, Veillette A (1998). "Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases". J. Biol. Chem. 273 (25): 15765–72. doi:10.1074/jbc.273.25.15765. PMID 9624175.
{{cite journal}}: نگهداری یادکرد:doi رایگان بینشان (رده) - Ma L, Mauro C, Cornish GH, Chai JG, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S, Marelli-Berg FM (2010). "Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance". PNAS. 107 (45): 19461–6. doi:10.1073/pnas.1011748107. PMC 2984185. PMID 20978210.
پیوند به بیرون
- مکان ژنوم PECAM1 انسانی و صفحهٔ جزئیات ژنی PECAM1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
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