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ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that...

poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational...

uptake of external cargo. ARF6 is involved in the uptake of major histocompatibility class 1 proteins. While it is assumed ARF6 is not needed for endocytosis...

freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate...

"Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress". Frontiers in Toxicology. 7. doi:10.3389/ftox...

G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P (December 2003). "ARF6 controls post-endocytic recycling through its downstream exocyst complex...

in the cytosol rather than be degraded by the proteasome. CTA1 binds to ARF6-GTP (ADP-ribosylation factor 6) in the cytosol, which induces a conformational...

RAP1B; RAP2A; RAP2B; RAP2C Arf vesicular transport ARF1; ARF3; ARF4; ARF5; ARF6; ARL1; ARL2; ARL3; ARL4; ARL5; ARL5C; ARL6; ARL7; ARL8; ARL9; ARL10A; ARL10B;...

Tempst P, Spiegelman BM (1994). "Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and...

and diagnostics tools to cure cancer, specifically ARF6. Her research led to the discovery that ARF6 played a role in endosomal membrane trafficking and...

GTPases ADP-ribosylation factor (ARF) 1 and ARF5 and weak activity towards ARF6. The encoded protein is believed to function as an ARF GAP that controls...

component of the complex) and Arf small GTPases (such as ARF1, ARF5, and ARF6 ) or the similar protein ARL1, which causes dissociation of the CYFIP1-Nap1-Abi2...

categorized as class I (ARF1 and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene...

necessary for the pre-coupling. It has also been shown to interact with Arf6 and ARF1. Muscarinic acetylcholine receptor GRCh38: Ensembl release 89: ENSG00000133019...

Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (October 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". The Journal...

"CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration". Exp. Cell Res. 318 (3): 228–37. doi:10.1016/j...

phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization" (PDF). The Journal of...

exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation...

Schonteich E, Matheson J, et al. (2006). "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis". EMBO J. 24 (19):...

trisphosphate, V-ATPase and ARNO (a guanine nucleotide exchange factor of ARF6). These associations are thought to be predominantly involved in cellular...

vapor induces oxidative stress in human endothelial cells via activation of ARF6 and its guanine nucleotide exchange factor ARNO. This oxidative stress promotes...

large protein family of TRP ion channels. TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport...

CLIC/GEEC endocytic pathway, which is regulated by GRAF1. Each of RhoA, Arf6, or Cdc42 has the capacity to modulate one of the three distinct clathrin-independent...

Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis"...

infection. Amastigotes of L. donovani enter macrophages via a Rac1- and Arf6-dependent process, and are found in phagocytic vacuoles that interact with...

'KIAA1110', under which name it was found to act as a GEF for Arf1 but not Arf6. It is related to the other Arf-GEF protein IQSEC1. "www.genenames.org"....

exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar. GRCh38: Ensembl release...

4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/s0092-8674(00)81540-8...

5)P2)-rich membranes and signals to endosomes, leading to activation of ARF6, a key regulator of endocytosis. A-Raf may contribute to tumorigenesis through...

S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Curr. Biol. 17 (8): 711–6. Bibcode:2007CBio...

exchange factor for Rac/Cdc42, and GIT1, a GTPase activating protein for ARF6 implicated in receptor recycling and exocytosis. SCRIB is found in the cell...

phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6". The Journal of Biological Chemistry. 275 (18): 13901–6. doi:10.1074/jbc...

as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein...

cytoskeleton remodeling through interacting with cytohesin-2 (ARNO) and Arf6. ALDOA is ubiquitously expressed in most tissues, though it is predominantly...

class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene...

humans is encoded by the ARFIP2 gene. ARFIP2 has been shown to interact with Arf6, ARF3, ARF5 and RAC1. GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl...

initiates unfolded protein response (UPR) by activating Ire1, Xbp1, and Arf6, allowing the plasma B cells to produce vast amounts of antibody. BLIMP-1...

(November 2006). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". Journal...

membrane trafficking. CYTH2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. CYTH2 protein is 83% homologous to CYTH1. Two transcript variants encoding...

K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". The Journal...

HGNC:654; P61204 920 ARF4 HGNC:655; P18085 921 ARF5 HGNC:658; P84085 922 ARF6 HGNC:659; P62330 923 ARFGAP1 HGNC:15852; Q8N6T3 924 ARFGAP2 HGNC:13504; Q8N6H7...

TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004...

H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6". Molecular and Cellular Biology. 23 (2): 645–54. doi:10.1128/MCB.23.2.645-654...

epithelial cell surface polarity. EXOC5 has been shown to interact with Arf6. GRCh38: Ensembl release 89: ENSG00000070367 – Ensembl, May 2017 GRCm38:...

domain that binds PI(3,4,5)P3 in vitro. ARAP1 prefers Arf1 and Arf5 over Arf6 as substrate. The GAP activity exerted on Rho proteins is not dependent on...

further pack helically onto the membrane. CENTB1 interacts with GTP-bound ARF6, regulating polymerization of the actin cytoskeleton around the plasma membrane...

centromeric protein CENPH, the BAX Inhibitor TMBI4, the ADP ribosylation factor ARF6, the kinase TNIK, and the transcriptional repressor T22D1. The number of...

class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene...

co-complex interactions. CAC1A, QCR1, UQCRC1, CACNA1A, STOM, a8k1f4, HLA-B, ARF6, and Mapk3 have been found to interact with UQCRC2. GRCh38: Ensembl release...

(November 2009). "Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity". Nat. Cell Biol. 11 (11): 1325–31. doi:10.1038/ncb1976. PMC 2854659...

Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (Nov 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". J Cell Biol...

Minetti C, Benfenati F, Fassio A, Zara F (September 2010). "TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy"...

and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this...

"Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6". Journal of Cell Science. 131 (12) jcs213314. doi:10.1242/jcs.213314. PMC 6031383...

M211397200. PMID 12682053. Krauss M, Kinuta M, Wenk MR, et al. (2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating...

clathrin-mediated endocytosis. Arrestin beta 1 has been shown to interact with Arf6, PTHLH, DVL2 Mdm2, OPRD1, PSCD2, and RALGDS. GRCh38: Ensembl release 89:...

Sun-Wada GH, Bourgoin S, et al. (2006). "V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway". Nat. Cell...

with partner proteins, and a C-terminal tail domain, which includes the Arf6-interacting domain important for regulatory functions. The protein exists...

4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/S0092-8674(00)81540-8...

Klausner, R. D. (1995-03-15). "Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments". J Cell...

(Dec 2002). "HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway". Cell. 111 (6): 853–66. doi:10.1016/S0092-8674(02)01162-5...

organization and neuronal development in the brain by reduced activation of the ARF6 substrate or a defect in the GTP-binding activity. Two intragenic duplications...

CDC42, CDH1, CLIP1, PRKACA, RAC1, and S100B. Actin – cytoskeletal structure ARF6 APC Beta-catenin–cell adhesion and WNT signaling: transcription B-raf – MAPK...

(Apr 2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane". Current Biology. 17 (8): 711–6...

Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V (July 2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating...

major histocompatibility complex class I down-modulation is independent of Arf6 activity". Molecular Biology of the Cell. 15 (1): 323–331. doi:10.1091/mbc...