ARFIP2

ARFIP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDsOMIM: 601638; MGI: 1924182; HomoloGene: 8234; GeneCards: ARFIP2; OMA:ARFIP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

23647

76932

Ensembl

ENSG00000132254

ENSMUSG00000030881

UniProt

P53365

Q8K221

RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)

NP_084078

Location (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.28 – 105.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]

Interactions

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030881 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
  6. ^ a b c Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  7. ^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. ^ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  9. ^ a b c Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  10. ^ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. S2CID 4324211.

Further reading

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