IQSEC1

IQSEC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIQSEC1, ARF-GEP100, ARFGEP100, BRAG2, GEP100, IQ motif and Sec7 domain 1, IQ motif and Sec7 domain ArfGEF 1, IDDSSBA
External IDsOMIM: 610166; MGI: 1196356; HomoloGene: 82429; GeneCards: IQSEC1; OMA:IQSEC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9922

232227

Ensembl

ENSG00000144711

ENSMUSG00000034312

UniProt

Q6DN90

Q8R0S2

RefSeq (mRNA)

NM_001134382
NM_014869
NM_001330619
NM_001376938

NM_001134383
NM_001134384
NM_182784
NM_001356440

RefSeq (protein)

NP_001127854
NP_001317548
NP_055684
NP_001363867

NP_001127855
NP_001127856
NP_001343369

Location (UCSC)Chr 3: 12.9 – 13.28 MbChr 6: 90.63 – 90.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.[5][6]

Function

The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5.[6] This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling.[7] ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.[8]

It is highly expressed in the prefrontal cortex, and throughout the rest of the brain, and is believed to have a role in learning and memory, having been detected as phosphorylated in a phospho screen of the PSD.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144711 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034312 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IQSEC1 IQ motif and Sec7 domain 1".
  6. ^ a b Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, Moss J, et al. (February 2001). "ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2413–8. Bibcode:2001PNAS...98.2413S. doi:10.1073/pnas.051634798. PMC 30152. PMID 11226253.
  7. ^ Hiroi T, Someya A, Thompson W, Moss J, Vaughan M (2006). "GEP100/BRAG2: Activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and α-catenin". Proc. Natl. Acad. Sci. U.S.A. 103 (28): 10672–7. Bibcode:2006PNAS..10310672H. doi:10.1073/pnas.0604091103. PMC 1502290. PMID 16807291.
  8. ^ Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE (2006). "The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins". Curr. Biol. 16 (3): 315–20. Bibcode:2006CBio...16..315D. doi:10.1016/j.cub.2005.12.032. PMC 3600433. PMID 16461286.
  9. ^ Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL (May 2006). "Comprehensive identification of phosphorylation sites in postsynaptic density preparations". Mol. Cell. Proteomics. 5 (5): 914–22. doi:10.1074/mcp.T500041-MCP200. PMID 16452087.

Further reading


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