CYTH4

CYTH4
Identifiers
AliasesCYTH4, CYT4, DJ63G5.1, PSCD4, cytohesin 4, cytohesin-4
External IDsOMIM: 606514; MGI: 2441702; HomoloGene: 22750; GeneCards: CYTH4; OMA:CYTH4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

27128

72318

Ensembl

ENSG00000100055

ENSMUSG00000018008

UniProt

Q9UIA0

Q80YW0

RefSeq (mRNA)

NM_013385
NM_001318024

NM_028195

RefSeq (protein)

NP_001304953
NP_037517

NP_082471

Location (UCSC)Chr 22: 37.28 – 37.32 MbChr 15: 78.6 – 78.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.[5][6]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100055 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018008 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. ^ a b "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

Further reading


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