PURG

PURG
Identifikatori
AliasiPURG
Vanjski ID-jeviOMIM: 618041 MGI: 1922279 HomoloGene: 22747 GeneCards: PURG
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za PURG
Genomska lokacija za PURG
Bend8p12Početak30,995,802 bp[1]
Kraj31,033,715 bp[1]
Lokacija gena (miš)
Hromosom 8 (miš)
Hrom.Hromosom 8 (miš)[2]
Hromosom 8 (miš)
Genomska lokacija za PURG
Genomska lokacija za PURG
Bend8|8 A3Početak33,876,353 bp[2]
Kraj33,907,495 bp[2]
Ontologija gena
Molekularna funkcija• vezivanje sa DNK
• vezivanje sa RNK
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
• double-stranded DNA binding
• purine-rich negative regulatory element binding
• sequence-specific DNA binding
Ćelijska komponenta• jedro
Biološki proces• GO:1901227 negative regulation of transcription by RNA polymerase II
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

29942

75029

Ensembl

ENSG00000172733

ENSMUSG00000049184

UniProt

Q9UJV8

Q8R4E6

RefSeq (mRNK)

NM_001015508
NM_013357
NM_001323311
NM_001323312

NM_001098233
NM_152821
NM_001382855

RefSeq (bjelančevina)

NP_001015508
NP_001310240
NP_001310241
NP_037489

NP_001091703
NP_690034
NP_001369784

Lokacija (UCSC)Chr 8: 31 – 31.03 MbChr 8: 33.88 – 33.91 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Purinom bogati element vezan za protein G je protein koji je kod ljudi kodiran genom PURG.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 347 aminokiselina, а molekulska težina 39.556 Da.[6]

1020304050
MERARRRGGGGGRGRGGKNVGGSGLSKSRLYPQAQHSHYPHYAASATPNQ
AGGAAEIQELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRGRQDNI
RKSKLTLSLSVAAELKDCLGDFIEHYAHLGLKGHRQEHGHSKEQGSRRRQ
KHSAPSPPVSVGSEEHPHSVLKTDYIERDNRKYYLDLKENQRGRFLRIRQ
TMMRGTGMIGYFGHSLGQEQTIVLPAQGMIEFRDALVQLIEDYGEGDIEE
RRGGDDDPLELPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRPPYRNTI
TVPFKAWTRFGENFIKYEEEMRKICNSHKEKRMDGRKASGEEQECLD

Funkcija

Tačna funkcija ovog gena nije poznata, ali njegov kodirani proizvod vrlo je sličan proteinu A, koji veže elemente purina (PURA). Ovaj posljednji je protein koji se veže za DNK i koji se prvenstveno veže za jedan lanac elementa bogatog purinom zvanog PUR; bio je uključen u kontrolu replikacije i transkripcije DNK. Ovaj gen je u neposrednoj blizini gena za Wernerov sindrom, ali na suprotnoj strani, na hromosomu 8, sekvenca p11. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.[5]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172733 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049184 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Purine-rich element binding protein G". Pristupljeno 27. 12. 2015.
  6. ^ "UniProt, Q9UJV8" (jezik: engleski). Pristupljeno 21. 9. 2021.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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