MOSC1

MTARC1
Identifikatori
AliasiMTARC1
Vanjski ID-jeviOMIM: 614126 MGI: 1913362 HomoloGene: 129604 GeneCards: MTARC1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za MTARC1
Genomska lokacija za MTARC1
Bend1q41Početak220,786,352 bp[1]
Kraj220,819,659 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za MTARC1
Genomska lokacija za MTARC1
Bend1|1 H5Početak184,518,964 bp[2]
Kraj184,543,510 bp[2]
Ontologija gena
Molekularna funkcija• molybdopterin cofactor binding
• molybdenum ion binding
• oxidoreductase activity
• pyridoxal phosphate binding
• nitrate reductase activity
• catalytic activity
Ćelijska komponenta• integral component of membrane
• membrana
• mitohondrija
• mitochondrial outer membrane
Biološki proces• detoxification of nitrogen compound
• nitrate metabolic process
• xenobiotic metabolic process
• metabolizam
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

64757

66112

Ensembl

ENSG00000186205

ENSMUSG00000026621

UniProt

Q5VT66

Q9CW42

RefSeq (mRNK)

NM_022746

NM_001081361
NM_001290273

RefSeq (bjelančevina)

NP_073583

NP_001277202

Lokacija (UCSC)Chr 1: 220.79 – 220.82 MbChr 1: 184.52 – 184.54 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Mitohondrijska amidoksim-reducirajuća komponenta 1, znana i kao protein 1 sa MOCO sulfuraznim C-terminalnim domenom, MOSC1 ili MARC1, jest enzim koji je kod ljudi kodiran genom sa hromosoma 1.[5][6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 337 aminokiselina, a molekulska težina 37.499 Da.[7]

1020304050
MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRR
LLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQE
GNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCR
VHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFR
PKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYA
EDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQC
DPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ

Funkcija

MOCO je engleska skraćenica za molibdenski [[kofaktor (biohemija)|cofaktor.

Prijavljeno je da MOSC1 reducira amidoksime na amidine.[8][9]

Prijavljeno je da su genetičke varijacije MARC1 povezane sa nižim nivoima holesterola u krvi, nivoima jetrenih enzima u krvi, smanjenom masnoćom jetre i zaštitom od ciroze, što sugeriše da nedostatak MARC1 može zaštititi od bolesti jetre.[10]

Također pogledajte

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186205 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026621 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anantharaman V, Aravind L (januar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol. Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
  6. ^ "Entrez Gene: Mitochondrial amidoxime reducing component 1". Pristupljeno 3. 3. 2016.
  7. ^ "UniProt, Q5VT66" (jezik: engleski). Pristupljeno 14. 12. 2021.
  8. ^ Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B (novembar 2006). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.
  9. ^ Gruenewald S, Wahl B, Bittner F, Hungeling H, Kanzow S, Kotthaus J, Schwering U, Mendel RR, Clement B (decembar 2008). "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs". J. Med. Chem. 51 (24): 8173–7. doi:10.1021/jm8010417. PMID 19053771.
  10. ^ Kathiresan, Sekar; Gabriel, Stacey; Denny, Joshua; Daly, Mark; Saleheen, Danish; Danesh, John; Gupta, Namrata; Erdmann, Jeanette; Baber, Usman (31. 3. 2019). "A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease". bioRxiv (jezik: engleski). 16 (4): 594523. doi:10.1101/594523. PMC 7200007. PMID 32282858.

Vanjski linkovi

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