FPGT

FPGT
Identifikatori
AliasiFPGT
Vanjski ID-jeviOMIM: 603609 MGI: 1922790 HomoloGene: 2847 GeneCards: FPGT
EC broj2.7.7.30
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za FPGT
Genomska lokacija za FPGT
Bend1p31.1Početak74,198,238 bp[1]
Kraj74,234,086 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za FPGT
Genomska lokacija za FPGT
Bend3|3 H4Početak154,790,555 bp[2]
Kraj154,799,040 bp[2]
Ontologija gena
Molekularna funkcija• aktivnost sa transferazom
• nucleotide binding
• transferase activity, transferring phosphorus-containing groups
• nucleotidyltransferase activity
• GTP binding
• catalytic activity
• fucose-1-phosphate guanylyltransferase activity
Ćelijska komponenta• citoplazma
• citosol
Biološki proces• fucose metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

8790

75540

Ensembl

ENSG00000254685

ENSMUSG00000053870

UniProt

O14772

G5E8F4

RefSeq (mRNK)

NM_003838
NM_001199328
NM_001199329

NM_029330

RefSeq (bjelančevina)

NP_001186257
NP_001186258
NP_003829

NP_083606

Lokacija (UCSC)Chr 1: 74.2 – 74.23 MbChr 3: 154.79 – 154.8 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Fukoza-1-fosfat guanililtransferaza jest enzim koji je kod ljudi kodiran genom FPGT sa hromosoma 1.[5][6]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 594 aminokiseline, a molekulska težina 66.599 Da.[7]

1020304050
MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQE
LAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLY
GDKWNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAM
YIDFPLNMNPGILVTCADDIELYSIGEFEFIRFDKPGFTALAHPSSLTIG
TTHGVFVLDPFDDLKHRDLEYRSCHRFLHKPSIEKMYQFNAVCRPGNFCQ
QDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSCEIDA
YGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLNVVV
LNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTS
CIIQSILDSRCSVAPGSVVEYSRLGPDVSVGENCIISGSYILTKAALPAH
SFVCSLSLKMNRCLKYATMAFGVQDNLKKSVKTLSDIKLLQFFGVCFLSC
LDVWNLKVTEELFSGNKTCLSLWTARIFPVCSSLSDSVITSLKMLNAVKN
KSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEISLKSSLM

Funkcija

L-fukoza je ključni šećer u glikoproteinima i drugim složenim ugljikohidratima jer može biti uključena u mnoge funkcionalne uloge ovih makromolekula, kao što je prepoznavanje ćelija-ćelija. Donor fukozila za ove fukozilovane oligosaharide je GDP-beta-L-fukoza.

Postoje dva alternativna puta za biosintezu GDP-fukoze; glavni put pretvara GDP-alfa-D-manozu u GDP-beta-L-fukozu. Protein kodiran ovim genom učestvuje u alternativnom putu koji je prisutan u određenim tkivima sisara, kao što su u jetri i bubrezima, a čini se da funkcioniše kao spasonosni put za ponovno korištenje L-fukoze koja proizlazi iz prometa glikoproteina i glikolipida.

Ovaj put uključuje fosforilaciju L-fukoze. kako bi se formirao beta-L-fukoza-1-fosfat, a zatim kondenzacijama beta-L-fukoza-1-fosfata sa GTP-om fukoza-1-fosfat gvanililtransferaze za formiranje GDP-beta-L-fukoze.[6]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000254685 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053870 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pastuszak I, Ketchum C, Hermanson G, Sjoberg EJ, Drake R, Elbein AD (Dec 1998). "GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme". J Biol Chem. 273 (46): 30165–74. doi:10.1074/jbc.273.46.30165. PMID 9804772.
  6. ^ a b "Entrez Gene: FPGT fucose-1-phosphate guanylyltransferase".
  7. ^ "UniProt, O14772" (jezik: eng.). Pristupljeno 27. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Vanjski linkovi

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.