CSRP2
Cisteinski i glicinski bogati protein 2 je protein koji je kod ljudi kodiran genom CSRP2.[5]
CSRP2 je član porodice gena CSRP, kodirajući grupu proteina LIM domena, koji mogu biti uključeni u regulatorne procese važne za razvoj i ćelijsku diferencijaciju. CRP2 sadrži dvije kopije motiva sekvence aminokiselina bogate cisteinom (LIM) s navodnom aktivnošću vezanja cinka i može biti uključen u regulaciju uređenog ćelijskog rasta. Ostali geni u porodici uključuju CSRP1 i CSRP3.[6][6][7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 20.954 Da.[8].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPVWGGGNKC | GACGRTVYHA | EEVQCDGRSF | HRCCFLCMVC | RKNLDSTTVA | ||||
| IHDEEIYCKS | CYGKKYGPKG | YGYGQGAGTL | NMDRGERLGI | KPESVQPHRP | ||||
| TTNPNTSKFA | QKYGGAEKCS | RCGDSVYAAE | KIIGAGKPWH | KNCFRCAKCG | ||||
| KSLESTTLTE | KEGEIYCKGC | YAKNFGPKGF | GYGQGAGALV | HAQ |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
- ^ a b "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".
- ^ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
- ^ "UniProt, Q16527". Pristupljeno 8. 8. 2021.
Dopunska literatura
- Jain MK, Fujita KP, Hsieh CM, et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.
- Karim MA, Ohta K, Egashira M, et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
- Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
- Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
- Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vanjski linkovi
- Lokacija ljudskog genoma CSRP2 i stranica sa detaljima o genu CSRP2 u UCSC Genome Browseru.
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