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CSRP1
Identifikatori
Aliasi	CSRP1
Vanjski ID-jevi	OMIM: 123876 MGI: 88549 HomoloGene: 37874 GeneCards: CSRP1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	201,509,456 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	135,679,970 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • vezivanje sa RNK; • vezivanje iona cinka;
Ćelijska komponenta	• Egzosom; • focal adhesion; • jedro;
Biološki proces	• platelet aggregation;
	Izvori:Amigo / QuickGO
Ortolozi
	1465
	13007
	ENSG00000159176
	ENSMUSG00000026421
	P21291
	P97315
	NM_004078; NM_001144773; NM_001193570; NM_001193571; NM_001193572
	NM_007791; NM_001360782
	NP_001180499; NP_001180500; NP_001180501; NP_004069
	NP_031817; NP_001347711
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cisteinom i glicinom-bogati protein 1 jest protein koji je kod ljudi kodiran genom CSRP1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 20.567 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPNWGGGKKC	GVCQKTVYFA	EEVQCEGNSF	HKSCFLCMVC	KKNLDSTTVA
VHGEEIYCKS	CYGKKYGPKG	YGYGQGAGTL	STDKGESLGI	KHEEAPGHRP
TTNPNASKFA	QKIGGSERCP	RCSQAVYAAE	KVIGAGKSWH	KACFRCAKCG
KGLESTTLAD	KDGEIYCKGC	YAKNFGPKGF	GFGQGAGALV	HSE

Funkcija

CSRP1 je član CSRP porodice gena koji kodiraju grupu LIM-domenskih proteina, koji mogu biti uključeni u regulatorne procese važne za razvoj i ćelijsku diferencijaciju. LIM/dvostruki motiv cinkovog prsta koji se nalazi u CRP1 nalazi se u grupi proteina s kritičnim funkcijama u regulaciji gena, rastu ćelija i somatskim diferencijacijama. Ostali geni u porodici uključuju CSRP2 i CSRP3.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159176 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026421 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.
^ Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910. S2CID 28018584.
^ ^a ^b "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".
^ "UniProt, P21291" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Weiskirchen R, Günther K (2003). "The CRP/MLP/TLP family of LIM domain proteins: acting by connecting". BioEssays. 25 (2): 152–62. doi:10.1002/bies.10226. PMID 12539241. S2CID 21364125.
Wang X, Lee G, Liebhaber SA, Cooke NE (1992). "Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc". J. Biol. Chem. 267 (13): 9176–84. doi:10.1016/S0021-9258(19)50405-7. PMID 1374386.
Wang X, Ray K, Szpirer J, et al. (1992). "Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism". Genomics. 14 (2): 391–7. doi:10.1016/S0888-7543(05)80231-9. PMID 1385304.
Feuerstein R, Wang X, Song D, et al. (1994). "The LIM/double zinc-finger motif functions as a protein dimerization domain". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10655–9. Bibcode:1994PNAS...9110655F. doi:10.1073/pnas.91.22.10655. PMC 45080. PMID 7938009.
Dubé JY, Chapdelaine P, Trahan PL, et al. (1998). "Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate". Arch. Androl. 40 (2): 109–15. doi:10.3109/01485019808987933. PMID 9507743.
Harper BD, Beckerle MC, Pomiès P (2001). "Fine mapping of the alpha-actinin binding site within cysteine-rich protein". Biochem. J. 350 Pt 1 (Pt 1): 269–74. doi:10.1042/0264-6021:3500269. PMC 1221251. PMID 10926853.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Hirasawa Y, Arai M, Imazeki F, et al. (2007). "Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma". Oncology. 71 (1–2): 77–85. doi:10.1159/000100475. PMID 17341888. S2CID 40174270.
Wang Q, Williamson M, Bott S, et al. (2007). "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer". Oncogene. 26 (45): 6560–5. doi:10.1038/sj.onc.1210472. PMID 17486081.

Vanjski linkovi

Lokacija ljudskog genoma CRP i stranica sa detaljima o genu CRP u UCSC Genome Browseru.
Lokacija ljudskog genoma CSRP1 i stranica sa detaljima o genu CSRP1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159176 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026421 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2115670-5] Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC 331088. PMID 2115670.

[pmid9925910-6] Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID 9925910. S2CID 28018584.

[entrez-7] "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

[UniProt-8] "UniProt, P21291" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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CSRP1

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

Vanjski linkovi

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