OR5V1
| OR5V1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR5V1, 6M1-21, hs6M1-21, olfactory receptor family 5 subfamily V member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2177493; HomoloGene: 73968; GeneCards: OR5V1; OMA:OR5V1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Functional studies of the mouse ortholog (Olfr110) have identified this receptor as a high-affinity sensor for the oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE), revealing a role beyond classical odorant detection in regulating metabolism. Engagement of this receptor by oxylipins activates Gs-dependent signaling pathways that promote fatty acid oxidation and influence glucose homeostasis, indicating a potential role for OR5V1 in metabolic processes and as a therapeutic target for metabolic disorders.[6]
See also
References
- ^ a b c ENSG00000227137, ENSG00000243441, ENSG00000243729, ENSG00000233046, ENSG00000230742, ENSG00000240130, ENSG00000242289 GRCh38: Ensembl release 89: ENSG00000112461, ENSG00000227137, ENSG00000243441, ENSG00000243729, ENSG00000233046, ENSG00000230742, ENSG00000240130, ENSG00000242289 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090894 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR5V1 olfactory receptor, family 5, subfamily V, member 1".
- ^ Ge XY, Cheng J, Zhang LJ, Guo LL, Xiang R, Lu Y, et al. (January 2026). "Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target". Cell. doi:10.1016/j.cell.2025.12.016. PMID 41570820.
Further reading
- Volz A, Ehlers A, Younger R, Forbes S, Trowsdale J, Schnorr D, et al. (May 2003). "Complex transcription and splicing of odorant receptor genes". The Journal of Biological Chemistry. 278 (22): 19691–19701. doi:10.1074/jbc.M212424200. PMID 12637542.
- Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
- OR5V1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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