OR11H7
| OR11H7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR11H7, OR11H7P, olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3030580; GeneCards: OR11H7; OMA:OR11H7 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) is a protein that in humans is encoded by the OR11H7 gene. [4]
Function
In most humans, OR11H7 is a pseudogene, meaning it does not result in the creation of a functional olfactory receptor protein that binds to specific odorants, although it may be functional in others. Other individuals, however, carry a single-nucleotide polymorphism on one or both chromosomes which transforms it from a pseudogene into an intact gene, and they are significantly more likely to exhibit hyperosmia to the chemical isovaleric acid. Isovaleric acid was shown to be a ligand of OR11H7.[5]
See also
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058188 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)". Retrieved 2020-04-13.
- ^ Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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