OR2W1
| OR2W1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OR2W1, hs6M1-15, olfactory receptor family 2 subfamily W member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3030097; HomoloGene: 12791; GeneCards: OR2W1; OMA:OR2W1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
Out of 10 human ORs studied, OR2W1 was the most broadly tuned, meaning it responds to the greatest variety of different odorant molecules.[6]
Ligands, in decreasing order of sensitivity:[6]
- 2-Heptanone
- 1-Octanal
- (-)-Citronellol
- Hexanal
- 3-Octanone
- Hexyl acetate
- 1-Hexanol
- Octanoic acid
- 1-Heptanol
- Allyl phenylacetate
- Benzyl acetate[7]
- 3,4-Hexanedione
See also
References
- ^ a b c ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 GRCh38: Ensembl release 89: ENSG00000204704, ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071522 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1".
- ^ a b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
- ^ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4) e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.
Further reading
- Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
- OR2W1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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