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Look up inhibition or inhibitor in Wiktionary, the free dictionary. Inhibitor or inhibition may refer to: Enzyme inhibitor, a substance that binds to an...

inhibition the substrate and inhibitor cannot bind to the enzyme at the same time. This usually results from the inhibitor having an affinity for the active...

inhibitor. An inhibitor that acts both in a cathodic and anodic manner is termed a mixed inhibitor. Copper surfaces. Benzotriazole is used to inhibit...

pharmacophore of SGLT inhibitors. Dapagliflozin is an example of an SGLT-2 inhibitor; it is a competitive, highly selective inhibitor of SGLT. It acts via...

A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...

necessary when taking a reversible inhibitor of MAO-A (i.e., moclobemide) or low doses of selective MAO-B inhibitors (e.g., selegiline 6 mg/24 hours transdermal...

A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...

lowering blood pressure. As a result of inhibiting the ACE enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin...

Protease inhibitor can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease Protease inhibitor (biology): molecules...

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4)...

Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; The other type is the butyryl-cholinesterase inhibitor. Acetylcholinesterase...

monoamine reuptake inhibitors to a lesser extent and hence are additionally NDRIs. Monoamine reuptake inhibitor Dopamine reuptake inhibitor Norepinephrine...

2009-06-28. Retrieved 2019-12-05. Pam Stephan. "PARP Inhibitor and DNA Polymerase Repair - PARP Inhibitor". About.com Health. Archived from the original on...

reuptake inhibitor Excitatory amino acid reuptake inhibitor (or glutamate-aspartate reuptake inhibitor) GABA reuptake inhibitor Glycine reuptake inhibitor Monoamine...

A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids. Neurosteroids include the excitatory neurosteroids...

C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement...

myostatin inhibitor. Resistance training reduces myostatin activity and increases follistatin activity. Pharmacological myostatin inhibitors can therefore...

TopII inhibitor), etoposide (TopII inhibitor), ciprofloxacin (fluoroquinolone, TopII inhibitor), and irinotecan (camptothecin derivative, TopI inhibitor) were...

protease inhibitors Classes of inhibitor mechanisms of action are: Suicide inhibitor Transition state inhibitor Protein protease inhibitor (see serpins)...

the most widely sold medications in the world. The class of proton-pump inhibitor medications is on the World Health Organization's List of Essential Medicines...

inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. Piclamilast, a more potent inhibitor than rolipram. Luteolin, supplement extracted...

A norepinephrine reuptake inhibitor (NRI), also known as a noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor, is a type of drug that acts...

checkpoint inhibitor treatment compared with studies of immune checkpoint inhibitor monotherapy. This holds promise for combining check point inhibitor therapy...

the inhibitor is released, the catalyst is again available for reaction. Inhibition should be distinguished from catalyst poisoning. An inhibitor only...

Thrombin inhibitor may refer to: Direct thrombin inhibitor Indirect thrombin inhibitor, such as warfarin This disambiguation page lists articles associated...

(SRA) Serotonin–norepinephrine reuptake inhibitor (SNRI) Serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) Barlow DH, durand VM (2009). "7:...

A volatile corrosion inhibitor (VCI) is a material that protects metals from corrosion. Corrosion inhibitors are chemical compounds that can decrease...

A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK...

non-peptidic proteasome inhibitor discovered was the natural product lactacystin. Disulfiram has been proposed as another proteasome inhibitor. Epigallocatechin-3-gallate...

A trypsin inhibitor (TI) is a protein and a type of serine protease inhibitor (serpin) that reduces the biological activity of trypsin by controlling...

bupropion or adding a PDE5 Inhibitor have decreased symptoms of sexual dysfunction. Studies have shown that PDE5 Inhibitors, such as sildenafil (Viagra)...

List of 5α-reductase inhibitors Discovery and development of 5α-reductase inhibitors CYP17A1 inhibitor Neurosteroidogenesis inhibitor Ulrike Blume-Peytavi;...

the only viable option is thermodynamic inhibitors. Kelland, Malcolm et al. A New Class of Hydrate Inhibitor. 2000. http://www.iris.no/internet/student...

maturation inhibitor program in 2010. Others in development include BMS-2838232. Salzwedel K, Martin DE, Sakalian M (2007). "Maturation inhibitors: a new...

Nerve growth factor (NGF) inhibitors are a class of compounds that inhibit the action of the neurotrophin nerve growth factor by targeting NGF molecules...

v t e A demethylation inhibitor is a compound that blocks the removal of methyl groups. It blocks enzymes (demethylases) from removing methyl groups....

reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI or TUI), is a type of drug that acts as a combined reuptake inhibitor of the...

HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance"...

Src inhibitor is a class of inhibitors[jargon] that targets the Src kinase family of tyrosine kinase, which is transcribed by the Src proto-oncogene (short...

Aromatase inhibitors have been approved for the treatment of gynecomastia in children and adolescents. Ovarian stimulation with the aromatase inhibitor letrozole...

Ariad's and Takeda's brigatinib (also an inhibitor of mutated EGFR) was the latest second-generation inhibitor and was approved in April 2017 by the US...

in mechanism and as such many polymerisation inhibitors act as radical scavengers. The term 'inhibitor' is often used in a general sense to describe...

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded...

inhibitors are chelating agents. The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking its activity. Other inhibitor mechanisms...

Cholinesterase inhibitors (ChEIs), also known as anti-cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine or...

A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout...

A CYP17A1 inhibitor is a type of drug that inhibits the enzyme CYP17A1. CYP17A1 inhibitors work by blocking specific enzyme functions, impacting androgen...

A portmanteau inhibitor is a drug that is a combination of two drug molecules, each of which is itself a type of inhibitor. The term was coined in 2007...

An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and...

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) that limits the activity of protein C (an anticoagulant). An N-terminal fragment...

DPP-4 inhibitors could cause joint pain that can be severe and disabling. However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users...

BET inhibitors in combination with γ-secretase inhibitors for T-cell acute lymphoblastic leukemia and BRAF-inhibitor (vemurafenib) for BRAF-inhibitor resistant...

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a novel class of oral medications developed for the treatment of anemia in chronic...

the substrate in the enzyme is decreased in the presence of an inhibitor. The inhibitor may bind to the enzyme regardless of whether the substrate has...

cardiovascular diseases if not managed. An example of a lipase inhibitor is orlistat. Lipase inhibitors may affect the amount of fat absorbed, yet they do not...

polymerase inhibitor sofosbuvir approved. Dasabuvir was approved in 2014. 2014 – The first NS5A inhibitor ledipasvir was approved. Four other NS5A inhibitors of...

thiocyanate - a chemical RNase inhibitor. PDB: 2BNH​; Kobe B, Deisenhofer J (1993). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich...

A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action...

(January 2022). "Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension". Cardiology in Review. 30 (1): 50–55. doi:10...

A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). They are intended to reduce the risk of atherosclerosis...

An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety of proteins required for...

II that facilitates blood pressure. Renin inhibitor is often preceded by direct, called direct renin inhibitor in order to distinguish its mechanism from...

A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by preventing overproliferation...

A progesterone synthesis inhibitor, or progestogen synthesis inhibitor, is a type of drug which inhibits the enzymatic synthesis of progesterone. They...

An enkephalinase inhibitor is a type of enzyme inhibitor which inhibits one or more members of the enkephalinase class of enzymes that break down the endogenous...

of COX-2 inhibitors. The inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of the selective COX-2 inhibitor celecoxib...

with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor. Tissue factor pathway inhibitor has been shown to interact with...

bacteria (containing the inhibitor acarbose). A crystal structure has been determined for tendamistat, the 74-amino acid inhibitor produced by Streptomyces...

the SERPING1 gene, which encodes the C1 inhibitor protein, and type III, now called HAE with normal C1 inhibitor (HAE-nl-C1INH). Types I and II affect females...

inhibitors of human proteases may be used to treat cancer. See the articles matrix metalloproteinase inhibitor (–mastat) and proteasome inhibitor (–zomib)...

protease inhibitor Renin inhibitors Aliskiren Ciprokiren Ditekiren Enalkiren Pepstatin Remikiren Terlakiren Zankiren Exopeptidase inhibitor Enkephalinase...

inhibitor." Enfuvirtide binds to gp41 and interferes with its ability to approximate the two membranes. It is also referred to as a "fusion inhibitor...

Steroidogenesis inhibitor Androgen synthesis inhibitor Progesterone synthesis inhibitor Bhatnagar, A. S.; Miller, W. R. (1999). "Pharmacology of Inhibitors of Estrogen...

mutations individually, making it a brain-penetrant second-generation RET inhibitor for which a clinical trial is open in the US since February 2021. In 2021...

tovinontrine, and PF-04447943. Cannabidiol acts as a PDE9 inhibitor in vitro. There are no PDE9 inhibitors that have been approved as of 2023. Zheng, Lei; Zhou...

An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT)...

causative agents have been excreted. Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening...

and ethanol (alcohol). Reuptake inhibitor Glycinergic GABA reuptake inhibitor Excitatory amino acid reuptake inhibitor Harsing LG, Juranyi Z, Gacsalyi...

and mTOR inhibitor) TG100-115 (mainly a PIK3CD and PIK3CG inhibitor) ZSTK474 (mainly a PIK3CD inhibitor) AEZS-136 (dual PI3K and ERK inhibitor) B591 (pan-class...

Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). It has been measured in coagulation...

A PPO inhibitor may inhibit two unrelated enzymes abbreviated "PPO". They are: Protoporphyrinogen oxidase inhibitors — Used as herbicides Polyphenol oxidase...

S2CID 22233833. Gadea, Bedrick B.; Ruderman, Joan V. (2005). "Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of...

aspirin because it inhibits the ability of the kidneys to excrete uric acid, and thus may exacerbate these conditions. If a COX-2 inhibitor is taken, a traditional...

dihydroxybergamottin) inhibit the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of most statins (however, it is a major inhibitor of only lovastatin...

A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic...

Tissue+Inhibitor+of+Metalloproteinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Media related to Tissue inhibitor of metalloproteinases...

STAT inhibitors are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of cytoplasmic induction factors. Inhibitors...

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response...

A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation...

An exopeptidase inhibitor is a drug that inhibits one or more exopeptidase enzymes. Exopeptidases are one of two types of proteases (enzymes that break...

Lipogenesis inhibitor is a class of drug that works by inhibiting de novo lipogenesis—the generation of fatty acids in the body. These drugs target enzymes...

lipase inhibitor on the market (October 2016) is orlistat (Xenical, Alli). Lipase inhibitors have also shown anticancer activity, by inhibiting fatty acid...

PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PD-L1 immune checkpoint...

inherited problem known as C1 esterase inhibitor deficiency, medications known as angiotensin-converting enzyme inhibitors, or a lymphoproliferative disorder...

A catechol-O-methyltransferase inhibitor (COMT inhibitor) is a drug that inhibits the enzyme catechol-O-methyltransferase. This enzyme methylates catecholamines...

Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK...

A monoamine reuptake inhibitor (MRI) is a drug that acts as a reuptake inhibitor of one or more of the three major monoamine neurotransmitters serotonin...

inhibitor induced colitis is an inflammatory condition affecting the colon (colitis), which is caused by cancer immunotherapy (checkpoint inhibitor therapy)...

have possible solutions in sight. The protease inhibitor ABT-493 and the next-generation NS5A inhibitor ABT-530 are considered active against all HCV genotypes...

A β-Lactamase inhibitor is a chemical compound that prevents bacterial degradation of β-lactam (beta-lactam) antibiotics. Beta-lactamases are a family...

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight...

serine protease inhibitors. One example of Sunflower trypsin inhibitor is Sunflower trypsin inhibitor-1 (SFTI-1). Sunflower trypsin inhibitor-1 is a potent...

sonidegib, both inhibitors of Smoothened (SMO), which are being used for the treatment of basal cell carcinoma. Arsenic trioxide, an inhibitor of GLI transcription...

protease inhibitor family of proteins consists of eukaryotic proteinase inhibitors, belonging to MEROPS inhibitor family I12, clan IF. They mainly inhibit serine...

A hypomethylating agent (or demethylating agent) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group...

The inhibitor protein (IP) is situated in the mitochondrial matrix and protects the cell against rapid ATP hydrolysis during momentary ischaemia. In oxygen...

patient taking an alpha-glucosidase inhibitor.[citation needed] Acarbose Alpha-glucosidase Alpha amylase inhibitor Cinnamon Moreira, Fernanda Duarte; Reis...

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT)...

A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that...

selective as a Bcr-Abl inhibitor and these changes resulted in the discovery of nilotinib. Nilotinib is a selective Bcr-Abl kinase inhibitor. Nilotinib is 10-30...

An inhibitor cystine knot (also known as ICK or Knottin) is a protein structural motif containing three disulfide bridges. Knottins are one of three folds...

ACE inhibitor therapy.[citation needed] More recently, they have been used for the treatment of heart failure in patients intolerant of ACE inhibitor therapy...

Bethesda unit (BU) is a measure of blood coagulation inhibitor activity. It is the amount of inhibitor that will inactivate half of a coagulant during the...

Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. There are various types of prostaglandins responsible for...

A serotonin–dopamine reuptake inhibitor (SDRI) is a type of drug which acts as a reuptake inhibitor of the monoamine neurotransmitters serotonin and dopamine...

(GlyT1) inhibitor Solriamfetol (Sunosi; JZP-110; SKLN05; ARL-N05; YKP-10A; R-228060; ADX-N05) – norepinephrine and dopamine reuptake inhibitor and trace...

PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). PCR inhibition is the most...

A GABA reuptake inhibitor (GRI), also known as a GABA transporter blocker, is a type of drug which acts as a reuptake inhibitor of the major inhibitory...

clearance. a Moderate inhibitor causes at least a 2-fold increase in the plasma AUC values, or 50–80% decrease in clearance. a Weak inhibitor causes at least...

Polygalacturonase inhibitor proteins (PGIPs), also known as polygalacturonase-inhibiting proteins, are plant proteins capable of inhibiting the action of...

PD1 inhibitor that was approved by the FDA in 2014. Pembrolizumab is approved to treat melanoma and lung cancer. Antibody BGB-A317 is a PD-1 inhibitor (designed...

(HAART). Ritonavir is a protease inhibitor, though it now mainly serves to boost the potency of other protease inhibitors. It may also be used in combination...

trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz-type soybean trypsin inhibitors are usually...

frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck...

neurological disorders, or osteoporosis. Members of carbonic anhydrase inhibitor group of medications include: acetazolamide, sulthiame, zonisamide, topiramate...

to identify ATP-competitive c-Met inhibitors in 2002 led to the discovery of K252a, a staurosporine-like inhibitor which blocks c-Met. K252a was the first...

A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and...

glycoprotein IIb/IIIa inhibitors, also GpIIb/IIIa inhibitors, is a class of antiplatelet agents. Several GpIIb/IIIa inhibitors exist: abciximab (abcixifiban)...

2014). "Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors". Journal of Clinical...

high selectivity against closely related proteins because although the inhibitor might bind transiently to the active sites of such proteins, it will not...

agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus...

VEGFR-2 inhibitor, also known as kinase insert domain receptor(KDR) inhibitor, are tyrosine kinase receptor inhibitors that reduce angiogenesis or lymphangiogenesis...

family of Acyl-CoA-binding proteins. This gene encodes diazepam binding inhibitor, a protein that is regulated by (and regulates the release of) hormones...

A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition...

methionine in alpha1-antitrypsin as an inhibitor of tissue elastase and on arginine in antithrombin as an inhibitor of thrombin. The critical role of the...

An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by...

A GABA transaminase inhibitor is a drug that acts as an inhibitor of the enzyme GABA transaminase (GABA-T), which metabolizes the major inhibitory neurotransmitter...

GM, Lock RB, Liu T (May 2016). "The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression...

analog, compounds with similar chemical structure Enzyme inhibitor Substrate analog Suicide inhibitor Substrate Silverman RB (2004). The Organic Chemistry...

carboxypeptidase A inhibitor family is a family of proteins which is represented by the well-characterised metallocarboxypeptidase A inhibitor (MCPI) from potatoes...

Redemption Ark, Absolution Gap, and Inhibitor Phase deals with humanity coming to the attention of the Inhibitors and the resultant war between them....

expressed to decrease hormone secretion. Mainly, as a neuroendocrine inhibitor, it exerts its effects on the gastrointestinal tract, pancreas, hypothalamus...

Elvitegravir is a low-molecular-weight, highly selective integrase inhibitor that shares a core structure with quinolone antibiotics. A similar fixed-dose...

needed] The disulfide binding of the inhibitor takes place in the luminal sector of the H+/K+ ATPase where 2 mol of inhibitor is bound per 1 mol of active site...

acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA...

before deciding on whether warfarin or a DOAC or which direct factor Xa inhibitor is used, include: the presence or absence of valvular heart disease, state...

nonenzymatically cleaved to mercaptopurine, that acts as a purine analogue and an inhibitor of DNA synthesis. Mercaptopurine itself can also be administered directly...

decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, extracerebral decarboxylase inhibitor, DDCI and AAADI) is a medication of type enzyme inhibitor which...

"Clinical pharmacokinetics of laninamivir, a novel long-acting neuraminidase inhibitor, after single and multiple inhaled doses of its prodrug, CS-8958, in healthy...

Endocannabinoid system Reuptake inhibitor Cannabinoid receptor antagonist Endocannabinoid transporters FAAH inhibitor MAGL inhibitor Berger WT, Ralph BP, Kaczocha...

A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved...

unbreakable covalent bond between the inhibitor and the enzyme protein. Even if all unattached parts of the inhibitor are removed, the enzyme activity of...

inhibitor binds to the active site where it is modified by the enzyme to produce a reactive group that reacts irreversibly to form a stable inhibitor-enzyme...

most potent inhibitor. Later, the researchers compared a few mercaptoacyl amino acid inhibitors and concluded that the binding of the inhibitor to the enzyme...

Neu5Ac is also a mild inhibitor for the enzyme but as Neu5Ac2en is a transition-state analogue it is a much better inhibitor. In the beginning the X-ray...

(December 2005). "BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors". Cancer Research...

(L-DOPA), can also inhibit prolactin secretion. Antiestrogens such as aromatase inhibitors and GnRH analogues are also able to inhibit the secretion of...

Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that...

et al. (April 2002). "Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects" (PDF). Drug Metab. Dispos. 30 (4):...

Potato carboxypeptidase inhibitor (PCI) is a naturally occurring protease inhibitor peptide in potatoes that can form complexes with several metallo-carboxypeptidases...

bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It can be...

considered to be the predominant elastase inhibitor in secretions, while α1-antitrypsin is the predominant elastase inhibitor in tissues. Several diseases, including...

(2003). "The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases...

serrata (Indian Frankincense) has been found to inhibit 5-lipoxygenase strongly as an allosteric inhibitor. Boswellia administration has been shown to reduce...

inhibitors; Pictilisib is another pan-PI3K inhibitor with greater subunitα-inhibitor activity than buparlisib. Idelalisib is the first PI3K inhibitor...

Cao J, Tan C, Ma D, et al. (2025). "A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial". Nature...

HIV-1 capsid protein, and the most promising peptide inhibitor was the capsid assembly inhibitor (CAI) peptide. CAI prevented the formation of mature...

or PP-405, is a drug acting as a mitochondrial pyruvate carrier (MPC) inhibitor which is under development for the treatment of alopecia (hair loss),...

has been identified as a potential treatment for the disorder, and an inhibitor compound (MK-8189) is as of February 2023 in Phase 2b clinical development...

III trials currently in development. BIBF 1120 is a triple angiokinase inhibitor developed by Boehringer Ingelheim which blocks the receptors for vascular...

a vasodilator and an inhibitor of norepinephrine release from postganglionic sympathetic nerves terminals (dopamine can inhibit norepinephrine release...

Adrenergic release inhibitors are a class of drugs which inhibit the release of epinephrine (adrenaline) and/or norepinephrine (noradrenaline) from adrenergic...

bound to the inhibitor, the substrate, or neither, but it cannot bind both at the same time. During competitive inhibition, the inhibitor and substrate...

thus treat or cure HCV. They are often used in combination with NS5A inhibitors. Beclabuvir, currently in clinical trials. Dasabuvir (Viekira Pak),...

lymphoma (SLL) Ibrutinib (Imbruvica), a selective Bruton's tyrosine kinase inhibitor. Orelabrutinib, approved in China for patients with mantle cell lymphoma...

ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth. ACE inhibitors reduce...

A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate....

A matrix metalloproteinase inhibitor (INN stem –mastat) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic...

not inhibit the reuptake of serotonin or other monoamines.[citation needed] medifoxamine (Clédial, Gerdaxyl) – a serotonin–dopamine reuptake inhibitor and...

therapy, including a Bruton's tyrosine kinase inhibitor. Sonrotoclax is contraindicated with strong CYP3A inhibitors at initiation and ramp-up phase due to potential...

non-nucleoside reverse transcriptase inhibitor; and islatravir, a nucleoside analog reverse transcriptase inhibitor. It is taken by mouth. Doravirine/islatravir...

Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular...

and the inhibitor affect each other. The enzyme's function is reduced but not eliminated when bound to the inhibitor. This type of inhibitor does not...

plant are also necessary for the production of these inhibitors. Once the proteinase inhibitor has been ingested by the insect, it presents itself as...

mTOR was made in 1994 while investigating the mechanism of action of its inhibitor, rapamycin. Rapamycin was first discovered in 1975 in a soil sample from...

phosphodiesterase PDE5 inhibitor – erectile dysfunction [3] Tadalafil oral film (Exordia; INT-007; INT0007; INT0007/2006) – phosphodiesterase PDE5 inhibitor – erectile...

serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, escitalopram, fluoxetine, sertraline), serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g....

angiogenesis inhibitor 1 Brain-specific angiogenesis inhibitor 2 Brain-specific angiogenesis inhibitor 3 Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y...

growing interest and the advances in allosterism, no allosteric thrombin inhibitor has yet reached the stage of clinical trials. Bivalent DTIs enjoy limited...

children with progeria, demonstrated the efficacy of a farnesyltransferase inhibitor (FTI). Tipifarnib Lonafarnib Reuter CW, Morgan MA, Bergmann L (September...

hypercholesterolaemia. It is a PCSK9 inhibitor. Enlicitide decanoate interacts with the LDL receptor binding domain of PCSK9 and inhibits its interaction with the...

injection into a vein. Acetazolamide is a first generation carbonic anhydrase inhibitor and it decreases the ocular fluid and osmolality in the eye to decrease...

patients at risk of substance abuse. Norepinephrine reuptake inhibitor Monoamine reuptake inhibitor Ding, Y.-S.; Naganawa, M.; Gallezot, J.-D.; Nabulsi, N.;...

gene. A protease inhibitor, it is also known as alpha1–proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases...

and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. TIMP2 functions as both an MMP inhibitor and an activator...

have been known to inhibit tyrosinase. Henceforth, the medical and cosmetic industries are focusing research on tyrosinase inhibitors to treat skin disorders...

The oocyte maturation inhibitor (OMI) is an inhibitory factor created by follicular cells during a primary oocyte maturation. It is believed to be the...

method to inhibit certain cancer types. Ras point mutations are the single most common abnormality of human proto-oncogenes. Ras inhibitor trans-farnesylthiosalicylic...

pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related...

an allosteric inhibitor of MCP-1 induced leukocyte chemotaxis, was quickly shown by leukocyte migration assay to be a functional inhibitor of many chemokines...

treatment. Combined treatment with a neprilysin inhibitor and an angiotensin converting enzyme (ACE) inhibitor has been shown to be effective in reducing angiotensin...

ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene. This gene encodes a mitochondrial ATPase inhibitor. Alternative...

domain belong to the MEROPS inhibitor family I2, clan IB; the Kunitz/bovine pancreatic trypsin inhibitor family, they inhibit proteases of the S1 family...

Medroxyprogesterone acetate and medrogestone are weak inhibitors of 3β-HSD which may substantially inhibit it at high dosages.[citation needed] Human steroidogenesis...

norepinephrine, dopamine, and/or serotonin) and release inhibitors such as botulinum toxin A (which inhibits acetylcholine release by inactivating SNAP-25, thereby...

Inhibitors (SSRIs) (December 2004). Weller IV (ed.). "Report of the CSM Expert Working Group on the Safety of Selective Serotonin Reuptake Inhibitor Antidepressants"...

DPP-4 inhibitor that showed effects in both animals and humans but it was not developed to a market drug due to side effects. Another old inhibitor is DPP-728...

8-hydroxyquinoline is an antifungal transcription inhibitor. The effects of histone methylation may also work to inhibit the action of transcription. Potent, bioactive...

therapeutic targets: protein structures, functions, and recent progress in inhibitor development". J. Steroid Biochem. Mol. Biol. 125 (1–2): 66–82. doi:10...

Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans". PLOS ONE. 7 (3) e33805...

the plant's defenses against some insect attacks is the cowpea trypsin inhibitor (CpTI). CpTI has been transgenically inserted into other crops as a pest...

Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. Autoxidation leads to degradation of organic compounds...

decrease in slope and a reduced maximum are obtained. Enzyme inhibitor Growth factor receptor inhibitor Selective receptor modulator "Pharmacology Guide: In vitro...

adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class. It is a peptidomimetic...

secretory trypsin inhibitor; avian ovomucoid; acrosin inhibitor; and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats. The...

(cAMP-dependent, catalytic) inhibitor alpha". Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent...

Yahya, Wan; Mansor, Nurlidia (2019). "Allicin incorporation as urease inhibitor in a chitosan/starch based biopolymer for fertilizer application". Materials...

selective and highly effective. The most effective aromatase inhibitor is letrozole; it can inhibit 99% of the aromatase enzyme in peripheral tissues. Some...

areata – ACVR1 protein inhibitor, Janus kinase 1 inhibitor, Janus kinase 2 inhibitor, Janus kinase 3 inhibitor, TYK2 kinase inhibitor Ivarmacitinib (ARQ-252...

include non-covalent inhibitor complexes and covalent adducts. The slime mold Dictyostelium discoideum produces a semispecific FAAH inhibitor. By controlling...

are inhibited by plasminogen activator inhibitor-1, plasminogen activator inhibitor-2, and protein C inhibitor. Produced mainly in the liver, plasminogen...

approved drugs that act as renal tubular transport inhibitors include: Probenecid: This is an inhibitor of the organic anion transport system, particularly...

{[S]}{K_{m}}}}}} where Ki is the binding affinity of the inhibitor, IC50 is the functional strength of the inhibitor, [S] is fixed substrate concentration and Km...

Mehta, Jodhbir S. (2015-03-16). "The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a...

Daraxonrasib (RMC-6236) is a RAS inhibitor drug. It is undergoing testing by Revolution Medicines to treat advanced solid tumors with RAS mutations, especially...

Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Their target, aldose reductase...

of migrane. Ketotifen Fenclonine (para-chlorophenylalanine; PCPA) An inhibitor of serotonin synthesis that has been used in the treatment of carcinoid...

Peptidase inhibitor 16 is a protein that in humans is encoded by the PI16 gene. GRCh38: Ensembl release 89: ENSG00000164530 – Ensembl, May 2017 GRCm38:...

androgen receptor (AR), androgen synthesis inhibitors like 5α-reductase inhibitors and CYP17A1 inhibitors, and antigonadotropins like GnRH analogues,...

treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane...

A gonadotropin release inhibitor is a substance that reduces the secretion of gonadotropins by the anterior pituitary gland. In particular, this means...

The inhibitor of apoptosis domain, also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR, is a structural motif found in...

secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein...

B-Raf inhibitors include GDC-0879, PLX-4720, Sorafenib, dabrafenib and encorafenib. Belvarafenib is classified as a panRAF inhibitor. A panRAF inhibitor blocks...

medications to eliminate Helicobacter pylori. Pantoprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It is available...

Pevonedistat (MLN4924) is a selective NEDD8 inhibitor. It is being investigated as a cancer treatment, e.g. for mantle cell lymphoma (MCL). NEDD8-activating...

a beta-lactam antibacterial and beta-lactamase inhibitor; and durlobactam, a beta-lactamase inhibitor. Sulbactam/durlobactam was approved for medical...

Allosteric serotonin reuptake inhibitor is a type of selective serotonin reuptake inhibitor (SSRI). Evidence of the allosteric action of escitalopram...

caused by an accumulation of protoporphyrin IX in the plant cells by inhibiting protox within the tetrapyrrole biosynthesis pathway. This is a potent...

Indobufen is a platelet aggregation inhibitor. It acts as a reversible cyclooxygenase inhibitor. The Merck Index (12th ed.). p. 4991. Eligini S, Violi...

tofacitinib was thought to be a selective JAK3 inhibitor, but later was found to be a potent inhibitor of JAK1 and JAK2. The value of developing a selective...

study fails to correct, then an inhibitor should be suspected. The most common inhibitor is a nonspecific inhibitor such as a lupus anticoagulant. Perform...

thrombophilia. Tissue factor pathway inhibitor (TFPI) limits the action of tissue factor (TF). It also inhibits excessive TF-mediated activation of FVII...

it effectively more of a norepinephrine reuptake inhibitor (NRI) than a dopamine reuptake inhibitor. Accordingly, the clinical effects of bupropion are...

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. This gene belongs to the tissue inhibitor of metalloproteinases...

ruxolitinib, a Janus kinase inhibitor (JAKi), but is not yet approved for clinical use. Pelabresib is a selective inhibitor of BET proteins (BRD2, BRD3...

chemical used as a fungicide. It is a steroid demethylation inhibitor (CYP51) , specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component...

acetylcholinesterase inhibitors have been used as insecticides and chemical weapons. Reversible inhibitors Monoamine oxidase inhibitors Enzyme inhibitor Millary,...

to some inhibitor binding to free enzymes regardless of the substrate's presence. As such, the extreme strength of uncompetitive inhibitors at high substrate...

Asundexian is a Factor XIa inhibitor developed by Bayer to prevent stroke. Asundexian efficacy and safety in patients have been evaluated in two clinical...

of the more potent angiotensin II. Captopril is an example of an ACE inhibitor. ACE cleaves a number of other peptides, and in this capacity is an important...

rather a mechanism of action class with diverse chemistries. The ALS inhibitor family includes sulfonylureas (SUs), imidazolinones, triazolopyrimidines...

Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase...

to the COX-2 isozyme are called COX-2 inhibitors. The active metabolite (AM404) of paracetamol is a COX inhibitor, a fact to which some or all of its therapeutic...

is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes...

seedlings of higher plants. Tropolone is a grape polyphenol oxidase inhibitor. Another inhibitor of this enzyme is potassium metabisulfite. Banana root PPO activity...

dissociation constant of roughly 10−15 M = 1 fM = 0.000001 nM. Ribonuclease inhibitor proteins may also bind to ribonuclease with a similar 10−15 M affinity...

the platelet. Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is greatly enhanced...

(ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for...

Toloxatone (Humoryl) Bifemelane (Alnert, Celeport) – RIMA, irreversible inhibitor of MAO-B, and weak NRI Atypical antipsychotics include: Amisulpride (Solian)...

reuptake inhibitor Dexmethylphenidate [controlled release] (CTX-1301) – norepinephrine–dopamine reuptake inhibitor Edivoxetine (LY-2216684) –...

Suzetrigine is a small-molecule non-opioid analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous...

protein SSI is a Subtilisin inhibitor-like which stands for Streptomyces subtilisin inhibitor. This is a protease inhibitor. These are often synthesised...

and triazolopyrimidine herbicide that acts as an acetolactate synthase inhibitor. It is primarily used for rice production. Penoxsulam's HRAC classification...

site and an enzyme inhibitor. If the enzyme found in bacteria is significantly different from the human enzyme then an inhibitor can be designed against...

organs but predominantly the lungs and the kidneys. Serpin peptidase inhibitor, clade A, member 1 (SERPINA1) is the gene that encodes the protein alpha-1...

specific signal, the signal is reset within the cell. Signal transduction inhibitor entry in the public domain NCI Dictionary of Cancer Terms  This article...

hormonal contraceptives inhibit follicular development and prevent ovulation as a primary mechanism of action. The ovulation-inhibiting dose (OID) of an estrogen...

recorded when administered with atenolol (beta blocker), enalapril (ACE inhibitor) and theophylline. Furosemide has drop effect on plasma level for tamsulosin...

is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, generalized anxiety...

inhibitors such as some biomass wastes, amino acids, and ionic liquids have been investigated. It is critical to choose the right corrosion inhibitor...

(reverse transcriptase inhibitor), dolutegravir (integrase inhibitor) and lamivudine (nucleoside analog reverse transcriptase inhibitor). Abacavir is a nucleotide...

while PCSK9 inhibitor treatment provides additional benefits beyond maximally tolerated statin therapy in high-risk individuals, PCSK9 inhibitor use probably...

inhibitor Entry inhibitor Discovery and development of non-nucleoside reverse transcriptase inhibitors Discovery and development of NS5A inhibitors Cuccioloni...

shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain. The low toxic effects of the inhibitor, in addition...

as a selective sirtuin 2 (SIRT2) inhibitor. It was one of the first selective SIRT2 inhibitors developed, and inhibits SIRT2 with an IC50 of 3.5μM, making...

example is strychnine, a convulsant poison, which acts as an allosteric inhibitor of the glycine receptor. Glycine is a major post-synaptic inhibitory neurotransmitter...

anti-cancer drug, which is a Bcl-2 inhibitor similar in action to obatoclax. In addition to Bcl-2, navitoclax also inhibits the related Bcl-xL and Bcl-w proteins...

and egg hatch, and thus act as insect growth regulators. They act by inhibiting chitin synthase, preventing the formation of chitin in the insect's body...

Inhibitors of CYP2D6 can be classified by their potency, such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values...

maneb, and mancozeb. These compounds are non-specific and are thought to inhibit cysteine-based protease enzymes. Similarly nonspecific are N-substituted...

treatment of bipolar disorder was the first natural GSK-3 inhibitor discovered. It inhibits GSK-3 directly by competition with magnesium ions and indirectly...

Factor Xa is inactivated by protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa...

136), levilimab (BCD-089), and CPSI-2364 an apparent macrophage-specific inhibitor of the p38 mitogen-activated protein kinase pathway. ALX-0061. e.g. for...

EAAT1 (GLAST) and EAAT2 (GLT-1). Reuptake inhibitor Glutamatergic GABA reuptake inhibitor Glycine reuptake inhibitor Excitatory amino acid receptor agonist...

is an inhibitor and likely substrate of schistosome P-glycoprotein. Elacridar and CP 100356 are other common[citation needed] P-gp inhibitors. Zosuquidar...

secreted protein that is an inhibitor of the epidermal growth factor receptor (EGFR) pathway in Drosophila melanogaster. Argos inhibits the EGFR pathway by sequestering...

genes. When used in combination with other drugs such as an ALK inhibitor or an MEK inhibitor, ribociclib has been shown to have a synergistic effect, resulting...

disulfiram (brand name Antabuse), which acts as an acetaldehyde dehydrogenase inhibitor, preventing the metabolism of acetaldehyde into acetic acid, and is used...

alkaline or electrically charged solutions. They inhibit certain blood proteases and show significant inhibitor activity. The alpha globulins typically have...

hypoglycemia, and recurrent infections. Cholesterol side-chain cleavage enzyme inhibitors include aminoglutethimide, ketoconazole, and mitotane, among others. Cholesterol...

Fuel system icing inhibitor (FSII) is an additive to aviation fuels that prevents the formation of ice in fuel lines. FSII is sometimes referred to by...

This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded...

order to limit the damage the collision would cause. Also central to the Inhibitor project was the eradication of all species above a certain technological...

Agios Pharmaceuticals previously developed the mIDH1 inhibitor ivosidenib and mIDH2 inhibitor enasidenib for treatment of acute myeloid leukemia (AML)...

kinase inhibitor. Many therapeutic approaches are aimed at the EGFR. Cetuximab and panitumumab are examples of monoclonal antibody inhibitors. However...

schedule. Olaparib acts as an inhibitor of the enzyme poly ADP ribose polymerase (PARP), and is termed a PARP inhibitor. BRCA1/2 mutations may be genetically...

partial agonist/reuptake inhibitor (SPARI), which can be applied only to vilazodone. Serotonin antagonist and reuptake inhibitors (SARIs) while mainly used...

biosynthesis inhibitor: mildronate 3-KAT inhibitors: trimetazidine 3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation...

an oligonucleotide telomerase inhibitor. By blocking telomerase activity, imetelstat causes telomere shortening, inhibits the proliferation of malignant...

metabolism of folic acid (it is an inhibitor of the dihydrofolate reductase). Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase and...

Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is...

Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the...

the clotting is reassessed. If a clotting inhibitor such as a lupus anticoagulant is present, the inhibitor will interact with the normal pooled plasma...

Agerafenib is a selective multi-kinase inhibitor. It is undergoing a trial to test its ability to treat malignant tumors in humans. It is effective in...

medicines, including tislelizumab, a checkpoint inhibitor, and zanubrutinib, a Bruton's tyrosine kinase inhibitor. On 14 November 2024 the company announced...

to suppress sebum production. H1-antihistamines refer to compounds that inhibit the activity of the H1 receptor. Since the H1 receptor exhibits constitutive...

(monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1. SerpinB1 is a cytoplasmic serine protease inhibitor of polymorphonuclear neutrophils...

cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes...

daunorubicin, an anthracycline topoisomerase inhibitor, and cytarabine, a nucleoside metabolic inhibitor. Daunorubicin/cytarabine is indicated for the...

inactive trypsinogen is then bound by the inhibitor. The protein-protein interaction between trypsin and its inhibitors is one of the tightest bound, and trypsin...

predominant isoform in the central nervous system. Tryptophan hydroxylase inhibitors include fenclonine (para-chlorophenylalanine or PCPA) and telotristat...

is a 5α-reductase inhibitor. It is specifically a selective inhibitor of the type II and III isoforms of the enzyme. By inhibiting these two isozymes...

and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Dichlorphenamide as a carbonic anhydrase inhibitor is used for the treatment...

of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis...

Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors and Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology...

(HIV-1) integrase strand transfer inhibitor; emtricitabine, an HIV-1 nucleoside analog reverse transcriptase inhibitor; and tenofovir alafenamide, an HIV-1...

and has molecular weight of 25 - 40kDa. It acts as a urinary trypsin inhibitor (UTI). Highly purified ulinastatin has been clinically used for the treatment...

with drugs that inhibit P-glycoprotein or BCRP may increase talazoparib concentrations in the body. Talazoparib acts as an inhibitor of poly ADP ribose...

cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer...

Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs...

by use of an aromatase inhibitor. Rapid onset of action and avoidance of initial gonadotropin flare with an aromatase inhibitor. Letrozole has been documented...

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide...

Ramipril, sold under the brand name Altace among others, is an ACE inhibitor type medication used to treat high blood pressure, heart failure, and diabetic...

norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release. N-Ethylpentedrone also slightly inhibits reuptake serotonin without its...

Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins comprise a family of proteins that heterodimerize with basic helix-loop-helix...

K-Ras(G12C) inhibitor 6 is an inhibitor of the oncogene KRAS. Its family of inhibitors allosterically control the GTP affinity of mutant K-Ras which is...

liver cytochrome P450 (CYP) pathway. To be specific, cimetidine is an inhibitor of the P450 enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4. By...

Norvir, was developed as a protease inhibitor and used to target HIV infection. However, it has been shown to inhibit proteasomes as well as free proteases;...

contains carbidopa, an inhibitor of aromatic amino acid decarboxylation; levodopa, an aromatic amino acid; and entacapone, an inhibitor of catechol-O-methyltransferase...

conclusion due to poor results. Another BACE1 inhibitor that has reached phase II trials is the Eli Lilly's inhibitor LY2886721. The data on phase I trial were...

phosphodiesterase 3 inhibitor and phosphodiesterase 4 inhibitor. It is given by inhalation. PDE3 inhibitors act as bronchodilators, while PDE4 inhibitors have an...

kidney disease. They are often used with other medications, such as ACE inhibitors or beta blockers. Increased urination is a commonly reported side effect...

Coadministration of a protease inhibitor with a PDE5 inhibitor is expected to substantially increase the PDE5 inhibitor concentration and may result in...

receptor and are marketed as antiplatelet agents. The combination of a P2Y12 inhibitor and aspirin, called dual antiplatelet treatment, remains the first-line...

including terutroban. Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. Ridogrel is another example...

alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR). Inhibitors of VEGFR are used in the treatment of cancer. Vascular endothelial growth...

Acquired C1 esterase inhibitor deficiency, also referred to as acquired angioedema (AAE), is a rare medical condition that presents as body swelling that...

allosteric modulators and enzyme affecting agents like enkephalinase inhibitors. BMS-986121: μ-PAM BMS-986122: μ-PAM BPRMU191: confers agonistic properties...

the case of a peptidase must include the active site, and for a protein inhibitor the reactive site. The classification is hierarchical: sequences are assembled...

Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646". www.rcsb.org. Retrieved January 19, 2025. Witwit, Haydar; Cubitt...

phosphoramidon have also been found to inhibit the enzymatic degradation of oxytocin. Enkephalinase inhibitor Tsujimoto M, Hattori A (2005). "The oxytocinase...

syndrome. It is in the class of medications known as proteasome inhibitor. It works by inhibiting proteasomes, cellular complexes that break down proteins....

a metastasis inhibitor. One elucidated pathway shows it interacts by cross-binding chromatin GC-rich promoter motifs, thereby inhibiting gene transcription...

primarily DHFR inhibitors, but raltitrexed is an inhibitor of thymidylate synthase, and pemetrexed inhibits both and a third enzyme. Antifolates act specifically...

decarboxylase (AAAD) inhibitor) [2] Altropane (123-I Altropane; [123I]-E-IACFT; NAV-5001; O-587) – dopamine reuptake inhibitor (DRI) and single-photon...

DMARDs fail, tocilizumab can be used for tumor necrosis factor (TNF) inhibitor treatments in NICE guidance. Combinations of DMARDs are often used, because...

Alzheimer's. The company sold the rights to Faldaprevir, a HCV protease inhibitor to Trek Therapeutics. In July 2016, the company sold the commercialisation...

an inhibitor of the enzyme monoamine oxidase (MAO) and hence is a monoamine oxidase inhibitor (MAOI). More specifically, it is a selective inhibitor of...

in the PDB. It has been shown in vitro to be a highly potent HIV entry inhibitor. It is currently being investigated as a potential microbicide for use...

was the first steroidal 5α-reductase inhibitor approved by the U.S. Food and Drug Administration (USFDA). It inhibits the function of two of the isoenzymes...

Conodurine is an acetylcholinesterase inhibitor and butyrylcholinesterase inhibitor isolated from Tabernaemontana. Conolidine Confoline Vieira, IJ; Medeiros...

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed...

Dihydropteroate synthase inhibitors are drugs that inhibit the action of dihydropteroate synthase. They include sulfonamides, dapsone, and para-aminosalicylic...

(2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of...

GBR-13119 is a psychostimulant and dopamine re-uptake inhibitor. Kilbourn, Michael R.; Phil S. Sherman; Teresa Pisani (1992). "Repeated reserpine administration...

phase-2 trials AKT inhibitor AZD5363 well tolerated, yielded partial response in patients with advanced solid tumors "PARP/AKT Inhibitor Combination Active...

amotivation. Monoamine synthesis inhibitors, such as the tryptophan hydroxylase inhibitor and serotonin synthesis inhibitor para-chlorophenylalanine (PCPA...

Okayama H (April 2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene...

developed a novel inhibitor of Bcl-2, Bcl-xL and Bcl-w, known as ABT-737. This compound is part of a group of BH3 mimetic small molecule inhibitors (SMI) that...

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is...

karyotyping to be performed. During cell division, demecolcine inhibits mitosis at metaphase by inhibiting spindle formation. Medically, demecolcine has been used...

Armine is an reversible acetylcholinesterase inhibitor. It is the ethylphosphonate analog of paraoxon. Paraoxon Ro 3-0419 Ro 3-0422 Reiner, E (December...

influenza, and Alzheimer's disease. Atomoxetine: a norepinephrine reuptake inhibitor used in the treatment of ADHD. AZD6765. Agmatine: Blocks NMDA receptors...

The cognate anion is called pyrazinoate. It inhibits panD, the aspartate 1-decarboxylase. It also inhibits Rv2783 (gpsI), a polyribonucleotide nucleotidyltransferase...

bradykinin inhibitors (antagonists) are being developed as potential therapies for hereditary angioedema. Icatibant is one such inhibitor. Additional...

NF-κB dimers are sequestered in the cytoplasm by a family of inhibitors, called IκBs (Inhibitor of κB), which are proteins that contain multiple copies of...

crops that are resistant to HPPD inhibitors and glufosinate. The collaboration to develop the stacked HPPD inhibitor/glyphosate resistant products was...

A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to...

growth by inhibiting germination, suppressing growth, and disrupting reproductive processes through toxic substance emissions. A germination inhibitor is a...

on the same protein as the cholesterol-lowering drugs known as PCSK9 inhibitors but, unlike them, is permanent. It works via base editing, a form of CRISPR...

of the analgesic paracetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI. Cannabinoid receptor Synthetic cannabinoid Cannabinoid receptor...

Protease inhibitor (pharmacology) Protease inhibitor (biology) TopFIND - database of protease specificity, substrates, products and inhibitors MEROPS -...

partial agonist and serotonin reuptake inhibitor SNTX-2643 (SENS-01) – atypical serotonin reuptake inhibitor (SRI) (kanna-derived) Dimethyltryptamine...

an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer, acting as a stemness inhibitor. Doxorubicin...

that acts as a selective urate reabsorption inhibitor that has uric acid lowering activity by inhibiting URAT1/SLC22A12 receptor. It and epaminurad are...

xenografts in response to (E)-2'-deoxy-2'-(fluoromethylene)cytidine, an inhibitor of ribonucleoside diphosphate reductase". Cancer Research. 54 (6): 1485–1490...

other ACE inhibitors, it is not a prodrug, is not metabolized by the liver, and is excreted unchanged in the urine. Lisinopril is an ACE inhibitor, meaning...

B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB...

enterogastrones is almost the same as gastric inhibitory polypeptide — i.e., to inhibit gastric secretion and stomach motility. Examples include: Secretin Cholecystokinin...

an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin. Enkephalinase inhibitor Yamamoto Y, Hashimoto J, Shimamura M, Yamaguchi...

for inhibitor potency and differences between isotypes of PDE in the Q2 pocket can be exploited for selectivity between isotypes. Drugs that inhibit PDE5...

numerical TEM designations. There are at least 19 distinct inhibitor-resistant TEM β-lactamases. Inhibitor-resistant TEM β-lactamases have been found mainly in...

arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. Rheumatoid arthritis and psoriatic...

functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. α2-macroglobulin...

inhibitor) – transient receptor potential TRPC4 and TRPC5 cation channel inhibitor [13] SNTX-2643 (SENS-01) – atypical serotonin reuptake inhibitor (SRI)...

while suppressing apoptosis by preventing caspase activation. cIAP1 is an inhibitor of apoptosis protein. It directly ubiquitinates RIP1 and induces constitutive...

Aleena. “Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department.” Annals of...

bleeding. Alpha-2-plasmin inhibitor deficiency is caused by mutations in the SERPINF2 gene, which encodes the alpha-2-plasmin inhibitor (Alpha 2-antiplasmin)...

and FAAH inhibitor JW-642 As well as the following compounds which are under pharmaceutical development: CC-97489 – dual MAGL and FAAH inhibitor Elcubragistat...

empagliflozin, and ertugliflozin. Canagliflozin was the first SGLT-2 inhibitor that was approved by the FDA, being accepted in March 2013. Dapagliflozin...

acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo...

cannot form disulfide bonds. It is also used in ubiquitin studies as an inhibitor of deubiquitinase enzymes (DUBs) because it alkylates the cysteine residues...

Moexipril was an angiotensin converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. Moexipril...

is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor (SSRI). It was investigated in the 1970s as a potential antidepressant...

another inhibitor to the malfunction enzyme that causes the leukemia. This inhibitor is a highly selective Bcr-Abl tyrosine kinase inhibitor. Sunitinib...

and stops synthesis; and IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating. FOLFIRI is used for...

made synthetically. It is a potent and selective inhibitor of the enzyme 15-lipoxygenase and inhibits oxygenation of linoleic acid, a process involved...

protease inhibitor) Darunavir (HIV protease inhibitor) Delavirdine (non-nucleoside reverse transcriptase inhibitor) Fosamprenavir (HIV protease inhibitor) Tipranavir...

is a cholinesterase inhibitor used in the management of myasthenia gravis. It is classified as a reversible cholinesterase inhibitor. Ambenonium exerts...

because of its dual mechanism as a serotonin-norepinephrine reuptake inhibitor. Serotonin syndrome caused by tramadol can be particularly problematic...

TM5441 is a drug which acts as an inhibitor of the serpin protein plasminogen activator inhibitor-1 (PAI-1). By inhibiting PAI-1, it increases activity of...

of hypertension (high blood pressure). It is an aldosterone synthase inhibitor. It is taken by mouth. Baxdrostat was approved for medical use in the...

and if positive for the BRAF V600 mutation, a BRAF inhibitor or BRAF inhibitor with an MEK inhibitor. Effectiveness was measured via the objective response...

key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic...

solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing...

for the treatment of desmoid tumors. It is a selective gamma secretase inhibitor that is taken by mouth. Nirogacestat was approved for medical use in the...

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4)...

Early Mitotic Inhibitor 1 (EMI1) is an important cell cycle regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome...

Divarasib (GDC-6036) is an experimental anticancer drug which acts as an inhibitor of the G12C mutant form of Kirsten rat sarcoma virus (KRAS), an oncogene...

substrate inhibitor (ESI) complex is formed. Similar to competitive inhibitors, the rate at product formation is decreased also. Lastly, mixed inhibitors are...

first HIV Integrase Strand Transfer Inhibitors (InSTIs) and leading the development of the first HIV integrase inhibitor to gain FDA approval, Isentress (raltegravir)...

intercalates into DNA; it as well interacts with topoisomerase II and inhibits DNA polymerases and therefore is used to treat cancer. "NCATS Inxight Drugs...

development of protein kinase inhibitors. It was founded in 1991, and shut down in 2003, after developing the pioneering kinase inhibitor drug sunitinib (Sutent)...

Cloricromen is a platelet aggregation inhibitor. Coronary vasodilator. Base catalyzed alkylation of ethyl acetoacetate (1) with 2-chlorotriethylamine...

"ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid...

Beta-lactamase inhibitor proteins (BLIPs) are a family of proteins produced by bacterial species including Streptomyces. BLIP acts as a potent inhibitor of beta-lactamases...

Selatogrel is a P2Y12 inhibitor that has been proposed as a treatment for acute myocardial infarction. Milluzzo RP, Franchina GA, Capodanno D, Angiolillo...

secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Brain-specific angiogenesis inhibitor 1 has been shown to interact...

medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam. The combination has activity against many Gram-positive and...

Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ARHGDIA gene. ARHGDIA has been shown to interact with: CDC42, RAC1, RHOA...

selectivity (rather than inhibit the target protein's enzymatic activity), efforts are underway to retool previously ineffective inhibitor molecules as PROTACs...

bind to the immunogenic hapten-protein adduct. An example of a hapten inhibitor is dextran 1, which is a small fraction (1 kilodalton) of the entire dextran...

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene. This gene encodes a trypsin inhibitor. The protein shares similarity to...

drug used for the treatment of shingles (herpes zoster). It acts as an inhibitor of the zoster virus's helicase–primase complex. Amenamevir was approved...

lines of therapy, including a Bruton tyrosine kinase inhibitor and a B-cell lymphoma 2 inhibitor. In the EU, lisocabtagene maraleucel is indicated for...

Zhuo L, Hascall VC, Kimata K (September 2004). "Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex". J. Biol. Chem...

concentrations of mCPP by 1.5-fold. Fluoxetine, a strong inhibitor of CYP2D6 and a weak or moderate inhibitor of CYP3A4, has been reported to increase levels of...

adenosine receptor antagonists (such as caffeine), and adenosine reuptake inhibitors. An adenosine antagonist has the opposite effects, but also modulates...

Sloan-Kettering researcher Paul Marks. Vorinostat was the first histone deacetylase inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment...

hydroxamic acid and acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor). Panobinostat was approved for medical use in the United States...

hand-foot syndrome. It is a prodrug to 5-FU, which is a thymidylate synthase inhibitor. It is metabolised to 5-FU by CYP2A6. Click on genes, proteins and metabolites...

Vosaroxin (AG-7352, SPC-595, SNS 595, voreloxin) is a topoisomerase II inhibitor causing site-selective DNA damage. It is under phase III clinical trial...

isolate. Sclerotiorin is an aldose reductase inhibitor (IC50=0.4 μM) as well as a reversible lipoxygenase inhibitor (IC50=4.2 μM). Chidananda, C; Rao, LJ; Sattur...

concomitant use with a CYP1A2 inhibitor can result in a higher concentration of ropinirole. When discontinuing the CYP1A2 inhibitor, if using both drugs, there...

selective PKC inhibitor. Other naturally occurring PKCIs are miyabenol C, myricitrin, gossypol. Bryostatin 1 can act as a PKC inhibitor; It was investigated...

a stable C-N bond. It inhibits the absorption and autolysis of bones and thus leads to lowering of blood calcium. It inhibits bone salts from dissolving...

serotonin–norepinephrine reuptake inhibitor (SNRI) [25] Ampreloxetine (TD-9855) – serotonin–norepinephrine reuptake inhibitor (SNRI) [26] ASP-8062 – GABAB...

pregnancy will likely harm the fetus. Etoposide is in the topoisomerase inhibitor family of medication. It is believed to work by damaging DNA. Etoposide...

GABAB receptor belongs to the class of G protein-coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate...

ISRIB (short for "integrated stress response inhibitor") is an experimental tool compound that blocks the integrated stress response, restoring the cell’s...

Bencyclane is an antispasmodic, vasodilator, and platelet aggregation inhibitor. Grignard addition of benzylmagnesiumbromide to suberone would give...

oxaloacetate is one of the most potent inhibitors of Complex II. Why a common TCA cycle intermediate would inhibit Complex II is not entirely understood...

indirect thrombin inhibitors, such as heparin. A short, synthetic peptide, it is a potent and highly specific inhibitor of thrombin that inhibits both circulating...

common fenoxy-phenoxy [sic] feature. This group of herbicides acts by inhibiting plant acetyl-CoA carboxylase (ACCase), a completely different mechanism...

a designer drug. It acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI). In July 2016 α-PiHP was first identified as a designer drug when...

reproduction. Cobicistat increases the effectiveness of the combination by inhibiting the liver and gut wall enzymes that metabolize elvitegravir. It is taken...

development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2". Journal of Enzyme Inhibition and...

single daily pill containing daclatasvir, a viral NS5A inhibitor, and sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase NS5B. It is on the World...

PKB/AKT. The bound BIM-1 inhibitor blocks bilobal interactions, the ATP-binding site, features an ATP-competitive inhibitor, 2-methyl-1H-indol-3-yl-BIM-1...

the brand name Dacogen among others, acts as a nucleic acid synthesis inhibitor. It is a medication for the treatment of myelodysplastic syndromes, a...

permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMK II) with IC50 of 900nM, charactered by hydrophobicity. KN-62 also potently inhibits the...

Tetradifon is a miticide. It acts by inhibiting mitochondrial ATP synthase and is in IRAC group 12C. Lippold, P. C (1966). "Comparison of Tetradifon Emulsifiable...

age-related macular degeneration. Avacincaptad pegol is a complement inhibitor. Avacincaptad pegol was approved for medical use in the United States...

anticipated to be introduced in 2028 for use in Brazil. It is a tubulin inhibitor that may be applied to soybeans, corn, and cotton among other crops. The...

susceptible IDH1 mutation. Olutasidenib is an isocitrate dehydrogenase-1 (IDH1) inhibitor. It is taken by mouth. The most common adverse reactions include nausea...

BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading...

Richard L. Lyman, was titled The isolation and purification of a trypsin inhibitor from whole wheat flour. Shyamala conducted research in UC Berkeley's Department...

Aurorix, Clobemix, Depnil and Manerix among others, is a reversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treat depression...

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. The protein encoded by this gene belongs to the inhibitor of DNA binding...

effects are joint and muscle pain in the arms or legs. Denosumab is an inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand), which...

very similar in structure. As a result, methotrexate is a competitive inhibitor of many enzymes that use folates. Methotrexate (green) complexed into...

codenamed PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis. It is being studied as a possible treatment for several...

An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be...

spontaneous urticaria. Remibrutinib is an oral, small molecule kinase inhibitor that inhibits Bruton's tyrosine kinase (BTK). It is taken by mouth. Remibrutinib...

dihydrochloride Vardenafil hydrochloride trihydrate Zaprinast Phosphodiesterase inhibitor This list was created from the NCI Thesaurus. "Otsuka's Moizerto Ointment...

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene. SPINT2 is a transmembrane protein with two extracellular...

discovered that (R)-phenylpiracetam is a selective atypical dopamine reuptake inhibitor in 2014. In addition, phenylpiracetam interacts with certain nicotinic...

that the different side groups determine potency of the inhibitor. The determinants of inhibitor specificity within the PDE2 active site are not very well...

investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without...

competitive non-selective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNFα and leukotriene synthesis, and reduces...

agent. It is an inhibitor of cellular respiration by blocking the respiratory chain at complex II. The first report of TTFA as an inhibitor of respiration...

similar zinc finger motifs and could potentially benefit from zinc finger inhibitor technology. Zinc ejectors were patented in 2008 and some have entered...

investigational new drug that is being evaluated to treat liposarcoma. It is a MDM2 inhibitor. "Milademetan - Rain Oncology". AdisInsight. Springer Nature Switzerland...

conducted. HAE is caused by a mutation of the C1-inhibitor gene. Defective or missing C1-inhibitor permits activation of kallikrein, a protease that...

PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene. Protein inhibitor of activated STAT2 has been shown to interact with: Androgen receptor...

The Diffusion Inhibitor is the first known attempt to build a working fusion power device. It was designed and built at the National Advisory Committee...

Woodman K, Abdel-Wahab N, Diab A (November 2019). "Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review...

cancer. It is a highly selective phosphoinositide 3-kinase inhibitor, and thus works by inhibiting the enzyme PIK3CG, disrupting the PI3K/AKT/mTOR signaling...

(brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast...

nervous system are called parasympathomimetics or cholinergics. Drugs that inhibit the parasympathetic system are called parasympatholytics or anticholinergics...

protein. A cyclin-dependent kinase inhibitor (CKI) is a protein that interacts with a cyclin-CDK complex to inhibit kinase activity, often during G1 phase...

member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis...

acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor. Gabaculine is also known as 3-amino-2,3-dihydrobenzoic...

β-lactamase inhibitor combination (cell wall synthesis inhibitor). FDA approved on 16 July 2019. Meropenem/vaborbactam: carbapenem/ β-lactamase inhibitor combination...

juice (which is a CYP3A4 inhibitor) increases the drug's maximum concentration by around 50%. Cilostazol is a selective inhibitor of phosphodiesterase type...

cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin-5 (also known...

Abscisic acid (also called ABA) is one of the most important plant growth inhibitors. It was discovered and researched under two different names, dormin and...

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded...

monoamine oxidase (MAO) inhibitor. It is a selective inhibitor of monoamine oxidase B (MAO-B) at lower doses but additionally inhibits monoamine oxidase A...

EMB-001) – combination of metyrapone (11β-hydroxylase inhibitor and cortisol synthesis inhibitor) and oxazepam (benzodiazepine/GABAA receptor positive...

carrier of otherwise insoluble calcium phosphate. Thus fetuin-A is a potent inhibitor of pathological calcification, in particular Calciphylaxis. Mice deficient...

the treatment of bronchiectasis. It is a dipeptidyl peptidase 1 (DPP1) inhibitor. It is taken by mouth. Brensocatib was approved for medical use in the...

morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally...

and the report that dutasteride inhibits 5α-R3 in vitro suggest that dutasteride may be a triple 5α reductase inhibitor. 5α-Reductase type 1 inactivated...

4-Diaminobutyric acid, also known as DABA, is GABA-T non-competitive inhibitor and a GABA reuptake inhibitor. In many bacteria, its (S) enantiomer is a natural product...

Linzagolixa Relugolix a = Under development; not yet marketed. Steroidogenesis inhibitor List of investigational sex-hormonal agents § GnRH/gonadotropins Riggs...

competitive inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity. Upon oral administration, tazemetostat selectively inhibits the...

Ruxolitinib is a Janus kinase inhibitor (JAK inhibitor) with selectivity for subtypes JAK1 and JAK2. Ruxolitinib inhibits dysregulated JAK signaling associated...

neuroinflammatory conditions. It is an orally active, selective, and reversible inhibitor of the NLRP3 inflammasome, a key component of the innate immune system...