en Fluacizine

Fluacizine
Clinical data
Trade names	Phtorazisin
Other names	Fluoracizine; Fluoracyzine; Fluoracisine; Ftoracizin; Ftoracizine; Phthoracizin
Routes of; administration	Oral, intramuscular injection
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 3-Diethylamino-1-[2-(trifluoromethyl)phenothiazin-10-yl]-propan-1-one;
CAS Number	30223-48-4 ; 27312-93-2 (hydrochloride);
PubChem CID	161562;
ChemSpider	141910 ;
UNII	E2M3325B1R;
ChEMBL	ChEMBL92281 ;
CompTox Dashboard (EPA)	DTXSID2046175 ;
Chemical and physical data
Formula	C20H21F3N2OS
Molar mass	394.46 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)C(=O)CCN(CC)CC;
	InChI InChI=1S/C20H21F3N2OS/c1-3-24(4-2)12-11-19(26)25-15-7-5-6-8-17(15)27-18-10-9-14(13-16(18)25)20(21,22)23/h5-10,13H,3-4,11-12H2,1-2H3 ; Key:VHEOUJNDDFHPGJ-UHFFFAOYSA-N ;
	(verify)

Fluacizine, sold under the brand name Phtorazisin, is a tricyclic antidepressant (TCA) of the phenothiazine group which is or was marketed in Russia.^[1]^[2]^[3] Unlike other phenothiazines, fluacizine is not an antipsychotic, and can actually reverse catalepsy and extrapyramidal symptoms induced by antidopaminergic agents like antipsychotics, reserpine, and tetrabenazine as well as potentiate amphetamine-induced stereotypy.^[3] It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic.^[4]^[5]^[6]^[7]^[3] The drug was developed in the 1960s and was marketed in the 1970s.^[1]^[4] It is the trifluoromethyl analogue of chloracizine.^[7]

References

^ ^a ^b ^c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 555–. ISBN 978-1-4757-2085-3.
^ ^a ^b O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1.
^ ^a ^b ^c V. V. Zakusov (22 October 2013). Pharmacology of Central Synapses. Elsevier. pp. 190–. ISBN 978-1-4831-4673-7.
^ ^a ^b Arefolov VA, Panasyuk LV, Raevskii KS, Kostyukov VI (1974). "Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens". Bull. Exp. Biol. Med. 77 (3): 295–7. doi:10.1007/BF00802484. PMID 4153328. S2CID 13188296.
^ Arefolov VA, Panasyuk LV (1974). "Effect of fluacizine on the uptake of exogenous noradrenalin". Bull. Exp. Biol. Med. 77 (5): 520–3. doi:10.1007/BF00797411. PMID 4441683. S2CID 27205700.
^ Arefolov VA, Panasiuk LV, Firsov VK (1975). "[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]". Farmakol Toksikol (in Russian). 38 (3): 285–9. PMID 6305.
^ ^a ^b Annual Reports in Medicinal Chemistry. Academic Press. 27 October 1972. pp. 19–. ISBN 978-0-08-058351-8.

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