Chemical compound
Pharmaceutical compound
Lafutidine AHFS /Drugs.com International Drug Names Routes of Oral ATC code
2-(furan-2-ylmethylsulfinyl)-N -[(Z )-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]acetamide
CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard (EPA ) ECHA InfoCard 100.118.935 Formula C 22 H 29 N 3 O 4 S Molar mass −1 3D model (JSmol )
C1CCCCN1Cc2ccnc(c2)OC/C=C\CNC(=O)CS(=O)Cc3ccco3
InChI=1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-
N Key:KMZQAVXSMUKBPD-DJWKRKHSSA-N
N N Y (what is this?) (verify)
Lafutidine (INN ) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to treat gastrointestinal disorders .[ 1]
Medical use
Lafutidine is used to treat gastric ulcers , duodenal ulcers , as well as wounds in the lining of the stomach associated with acute gastritis and acute exacerbation of chronic gastritis.[ 2] [ 3]
Adverse effects
Adverse events observed during clinical trials included constipation , diarrhea , drug rash , nausea , vomiting and dizziness .[ 3]
Mechanism of action
Like other H2 receptor antagonists , lafutidine acts by preventing the secretion of gastric acid .[ 3] calcitonin gene-related peptide , resulting in the stimulation of nitric oxide (NO) and regulation of gastric mucosal blood flow, increases somatostatin levels also resulting in less gastric acid secretion, causes the stomach lining to generate more mucin , inhibits neutrophil activation thus preventing injury from inflammation , and blocks the attachment of Helicobacter pylori [ 3]
Trade names
It is marketed in Japan as Stogar by UCB [ 2] Lafaxid by Zuventus Healthcare.[ 3] Ildong Lafutidine by Ildong Pharmaceutical Co Ltd.
References
H1
Agonists Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
H4
