en DR-4485

DR-4485
Identifiers
	IUPAC name 6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one;
CAS Number	402942-53-4 ;
PubChem CID	9911844;
ChemSpider	8087495;
CompTox Dashboard (EPA)	DTXSID901031962 ;
Chemical and physical data
Formula	C26H28Cl2N2O
Molar mass	455.42 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O;
	InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31); Key:SBTRHJHOLCAPFT-UHFFFAOYSA-N;

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT₇ receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.^[1]^[2]

References

^ Kikuchi C, Suzuki H, Hiranuma T, Koyama M (January 2003). "New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability". Bioorganic & Medicinal Chemistry Letters. 13 (1): 61–4. doi:10.1016/s0960-894x(02)00842-9. PMID 12467617.
^ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML (April 2009). "Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity". Journal of Medicinal Chemistry. 52 (8): 2384–92. doi:10.1021/jm8014553. PMID 19326916.

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[1] Kikuchi C, Suzuki H, Hiranuma T, Koyama M (January 2003). "New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability". Bioorganic & Medicinal Chemistry Letters. 13 (1): 61–4. doi:10.1016/s0960-894x(02)00842-9. PMID 12467617.

[2] Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML (April 2009). "Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity". Journal of Medicinal Chemistry. 52 (8): 2384–92. doi:10.1021/jm8014553. PMID 19326916.

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