Amorpha-4,11-diene 12-monooxygenase
Class of enzymes
Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating).[1] This enzyme catalyses the following chemical reaction
- amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ artemisinate + 3 NADP+ + 4 H2O (overall reaction)
- (1a) amorpha-4,11-diene + O2 + NADPH + H+ artemisinic alcohol + NADP+ + H2O
- (1b) artemisinic alcohol + O2 + NADPH + H+ artemisinic aldehyde + NADP+ + 2 H2O
- (1c) artemisinic aldehyde + O2 + NADPH + H+ artemisinate + NADP+ + H2O
Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)
References
External links
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CYP1 | |
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CYP2 | |
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CYP3 (CYP3A) | |
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CYP4 | |
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CYP5-20 | |
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CYP21-49 | |
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CYP51-69 | |
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CYP71-99 |
- CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1)
- CYP72A1
- CYP73A1
- CYP74 (D1)
- CYP75 (A1, B1)
- CYP76 (B6, M7)
- CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4)
- CYP80 (A1, B1, G2)
- CYP81 (E1, E3, E7, E9)
- CYP88D6
- CYP90C1
- CYP93E1
- CYP97C1
- CYP99A3
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CYP101-281 | |
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CYP301-499 | |
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CYP501-699 | |
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CYP701-999 | |
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