1,8-Cineole 2-endo-monooxygenase
Class of enzymes
1,8-Cineole 2-endo-monooxygenase (EC 1.14.14.133 , Formerly EC 1.14.13.156 , P450cin , CYP176A , CYP176A1 ) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-endo-hydroxylating) .[ 1] [ 2] [ 3] [ 4] This enzyme catalyses the following chemical reaction
1,8-cineole + NADPH + H+ + O2
⇌ ⇌ -->
{\displaystyle \rightleftharpoons }
2-endo-hydroxy-1,8-cineole + NADP+ + H2 O
1,8-Cineole 2-endo-monooxygenase is a heme -thiolate protein (P-450).
References
^ Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ (August 2002). "Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization" . The Journal of Biological Chemistry . 277 (31): 27725–32. doi :10.1074/jbc.M203382200 . PMID 12016226 .
^ Meharenna YT, Li H, Hawkes DB, Pearson AG, De Voss J, Poulos TL (July 2004). "Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam". Biochemistry . 43 (29): 9487–94. doi :10.1021/bi049293p . PMID 15260491 .
^ Kimmich N, Das A, Sevrioukova I, Meharenna Y, Sligar SG, Poulos TL (September 2007). "Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin" . The Journal of Biological Chemistry . 282 (37): 27006–11. doi :10.1074/jbc.M703790200 . PMID 17606612 .
^ Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ (April 2008). "The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin" . The Journal of Biological Chemistry . 283 (16): 10804–12. doi :10.1074/jbc.M709722200 . PMC 2447660 . PMID 18270198 .
External links
CYP1 CYP2 CYP3 (CYP3A ) CYP4 CYP5-20 CYP21-49 CYP51-69 CYP71-99
CYP71 (C1 , C2 , C3 , C4 , Z6 , AJ4 , AV1 , BA1 )
CYP72A1
CYP73A1
CYP74 (D1 )
CYP75 (A1 , B1 )
CYP76 (B6 , M7 )
CYP79 (A1 , A2 , B1 , B2 , B3 , D1 , D2 , D3 , D4 )
CYP80 (A1 , B1 , G2 )
CYP81 (E1 , E3 , E7 , E9 )
CYP88D6
CYP90C1
CYP93E1
CYP97C1
CYP99A3
CYP101-281 CYP301-499 CYP501-699 CYP701-999