Class of enzymes
Phenylalanine N-monooxygenase (EC 1.14.14.40, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating).[1] This enzyme catalyses the following chemical reaction
- L-phenylalanine + 2 O2 + 2 NADPH + 2 H+ (E)-phenylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
- (1a) L-phenylalanine + O2 + NADPH + H+ N-hydroxy-L-phenylalanine + NADP+ + H2O:
- (1b) N-hydroxy-L-phenylalanine + O2 + NADPH + H+ N,N-dihydroxy-L-phenylalanine + NADP+ + H2O
- (1c) N,N-dihydroxy-L-phenylalanine (E)-phenylacetaldoxime + CO2 + H2O
Phenylalanine N-monooxygenase is a heme-thiolate protein (P-450). It is part of the pathway in plants which converts phenylalanine to the glucosinolate, glucotropaeolin, which contributes to the characteristic flavor of brassicas.[2]
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