DOKUMEN123.COM

ZNF8
Identifikatori
Aliasi	ZNF8
Vanjski ID-jevi	OMIM: 194532 MGI: 2389445 HomoloGene: 10889 GeneCards: ZNF8
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	58,302,791 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	12,627,349 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • vezivanje iona cinka; • vezivanje iona metala; • nucleic acid binding;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • BMP signaling pathway; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	7554
	243833
	ENSG00000278129
	ENSMUSG00000060397
	P17098
	Q8BGV5
	NM_021089
	NM_153802
	NP_066575
	NP_722497
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 8 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF8.^[5]^[6]

Aminokiselinska sekvenca: Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAAARPEAQS	RSSPTPESRS	QEPLDLVLVP	DDCRPGTPPS	DLIEIQVVKV
TDTTLVPEPP	EPGSFHCALC	PAAFRLVSEL	LFHEHGHLAG	AEGGGQGGDP
SRCHVCGHSC	PGPASLRAHY	SLHTGERPYR	CALCPRAFKA	LAPLLRHQHR
HGVEPGTSRR	PPDTAAVAEQ	RPGVAPERAE	VVMAAAAAGA	AVGKPFACRF
CAKPFRRSSD	MRDHERVHTG	ERPYHCGICG	KGFTQSSVLS	GHARIHTGER
PFRCTLCDRT	FNNSSNFRKH	QRTHFHGPGP	GLGDSGGQLG	SSAAEGSGSG
CGVGDPAEEG	RGETAKVKVE	ADQ

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000278129 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060397 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lania L, Donti E, Pannuti A, Pascucci A, Pengue G, Feliciello I, La Mantia G, Lanfrancone L, Pelicci PG (Apr 1990). "cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes". Genomics. 6 (2): 333–40. doi:10.1016/0888-7543(90)90574-E. PMID 2106481.
^ ^a ^b "Entrez Gene: ZNF8 zinc finger protein 8".

Dopunska literatura

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jiao K, Zhou Y, Hogan BL (2002). "Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1". Mol. Cell. Biol. 22 (21): 7633–44. doi:10.1128/MCB.22.21.7633-7644.2002. PMC 135661. PMID 12370310.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000278129 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060397 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2106481-5] Lania L, Donti E, Pannuti A, Pascucci A, Pengue G, Feliciello I, La Mantia G, Lanfrancone L, Pelicci PG (Apr 1990). "cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes". Genomics. 6 (2): 333–40. doi:10.1016/0888-7543(90)90574-E. PMID 2106481.

[entrez-6] "Entrez Gene: ZNF8 zinc finger protein 8".

[1]

[2]

[3]

[4]

[5]

[6]

ZNF8

Interakcije

Reference

Dopunska literatura

Vanjski linkovi

Content Disclaimer