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ZNF76
Identifikatori
Aliasi	ZNF76
Vanjski ID-jevi	OMIM: 194549 MGI: 2687278 HomoloGene: 2569 GeneCards: ZNF76
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	35,295,985 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	28,424,860 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • vezivanje sa DNK; • nucleic acid binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of transcription by RNA polymerase III; • transcription by RNA polymerase II; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7629
	224656
	ENSG00000065029
	ENSMUSG00000024220
	P36508
	Q8BMU0
	NM_001292032; NM_003427
	NM_172617; NM_001357995
	NP_001278961; NP_003418
	NP_766205; NP_001344924
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta 76 jest protein koji je kod ljudi kodiran genom ZNF76.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 570 aminokiselina, а molekulska težina 61.831 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MESLGLHTVT	LSDGTTAYVQ	QAVKGEKLLE	GQVIQLEDGT	TAYIHQVTVQ
KEALSFEDGQ	PVQLEDGSMA	YIHRTPREGY	DPSTLEAVQL	EDGSTAYIHH
PVAVPSESTI	LAVQTEVGLE	DLAAEDDEGF	SADAVVALEQ	YASKVLHDSQ
IPRNGKGQQV	GDRAFRCGYK	GCGRLYTTAH	HLKVHERAHT	GDRPYRCDFP
SCGKAFATGY	GLKSHVRTHT	GEKPYKCPEE	LCSKAFKTSG	DLQKHVRTHT
GERPFQCPFE	GCGRSFTTSN	IRKVHVRTHT	GERPYTCPEP	HCGRGFTSAT
NYKNHVRIHT	GEKPYVCTVP	GCGKRFTEYS	SLYKHHVVHT	HCKPYTCSTC
GKTYRQTSTL	AMHKRSAHGE	LEATEESEQA	LYEQQQLEAA	SAAEESPPPK
RPRIAYLSEV	KEERDDIPAQ	VAMVTEEDGA	PQVALITQDG	AQQVSLSPED
LQALGSAISM	VTQHGSTTLT	IPSPDADLAT	SGTHTVTMVS	ADGTQTQPVT
IITSGAVVAE	DSSVASLRHQ	QVALLATANG	THIAVQLEEQ	QTLEEAINVA
TAAMQQGAVT	LETTVSESGC

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065029 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024220 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Dec 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.
^ "Entrez Gene: ZNF76 zinc finger protein 76 (expressed in testis)".
^ "UniProt, P36508" (jezik: engleski). Pristupljeno 4. 10. 2021.

Dopunska literatura

Prigge JR, Schmidt EE (2006). "Interaction of Protein Inhibitor of Activated STAT (PIAS) Proteins with the TATA-binding Protein, TBP". J. Biol. Chem. 281 (18): 12260–9. doi:10.1074/jbc.M510835200. PMC 2030495. PMID 16522640.
Zheng G, Yang YC (2006). "Acetylation and alternative splicing regulate ZNF76-mediated transcription". Biochem. Biophys. Res. Commun. 339 (4): 1069–75. doi:10.1016/j.bbrc.2005.11.122. PMID 16337145.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zheng G, Yang YC (2004). "ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation". J. Biol. Chem. 279 (41): 42410–21. doi:10.1074/jbc.M407287200. PMID 15280358.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Myslinski E, Krol A, Carbon P (1998). "ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf". J. Biol. Chem. 273 (34): 21998–2006. doi:10.1074/jbc.273.34.21998. PMID 9705341.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065029 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024220 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427894-5] Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Dec 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.

[entrez-6] "Entrez Gene: ZNF76 zinc finger protein 76 (expressed in testis)".

[UniProt-7] "UniProt, P36508" (jezik: engleski). Pristupljeno 4. 10. 2021.

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ZNF76

Aminokiselinska sekvenca

Reference

Dopunska literatura

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