ZNF334

ZNF334
Identifikatori
AliasiZNF334
Vanjski ID-jeviMGI: 2388656 HomoloGene: 23076 GeneCards: ZNF334
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[1]
Hromosom 2 (miš)
Genomska lokacija za ZNF334
Genomska lokacija za ZNF334
Bend2|2 H3Početak165,216,184 bp[1]
Kraj165,230,179 bp[1]
Ontologija gena
Molekularna funkcija• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• vezivanje sa DNK
• vezivanje iona metala
• nucleic acid binding
• GO:0001948, GO:0016582 vezivanje za proteine
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta• intracellular anatomical structure
• jedro
Biološki proces• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

55713

228876

Ensembl

ENSG00000198185

ENSMUSG00000017667

UniProt

Q9HCZ1

A2A4U6

RefSeq (mRNK)

NM_001270497
NM_018102
NM_199441

NM_178411

RefSeq (bjelančevina)
NP_001257426
NP_060572
NP_001340742
NP_001340743
NP_001340744

NP_001340745
NP_001340746
NP_001340747
NP_001340748
NP_001340749
NP_001340750
NP_001340751
NP_001340752
NP_001340753
NP_001340754
NP_001340755
NP_955473

NP_848498

Lokacija (UCSC)n/aChr 2: 165.22 – 165.23 Mb
PubMed pretraga[2][3]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 334 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF334.[4]

Ontologija

Molekulsdka funkcija
  • GO: 0001131, GO: 0001151, GO: 0001130, GO: 0001204
  • aktivnost transkripcionog faktora koji veže DNK
  • vezivanje DNK
  • vezivanje metalnih iona
  • vezivanje nukleinske kiseline
  • GO: 0001948 vezivanje za proteine
  • GO: 0001200, GO: 0001133, GO: 0001201 Aktivnost transkripcionog faktora koji veže DNK, specifičan za RNK- polimerazu II
Ćelijska komponenta
  • unutarćelijska anatomska struktura
  • jedro
Biološki proces
  • regulacija transkripcije, sa predloškom DNK
  • transkripcija, sa predloškom DNK
  • regulacija transkripcije RNK polimerazom II
Izvori: Amigo / QuickGO

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

1020304050
MKMKKFQIPVSFQDLTVNFTQEEWQQLDPAQRLLYRDVMLENYSNLVSVG
YHVSKPDVIFKLEQGEEPWIVEEFSNQNYPDIDDALEKNKEIQDKHLTQT
VFFSNKTLITERENVFGKTLNLGMNSVPSRKMPYKCNPGGNSLKTNSEVI
VAKKSKENRKIPDGYSGFGKHEKSHLGMKKYRYNPMRKASNQNENLILHQ
NIQILKQPFDYNKCGKTFFKRAILITQKGRQTERKPNECNECRKTFSKRS
TLIVHQRIHTGEKPYVCSDCRKTFRVKTSLTRHRRIHTGERPYECSECRK
TFIDKSALIVHQKIHGGEKSYECNECGKTFFRKSALAEHFRSHTGEKPYE
CKECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTFFCQSALTAHQRIHT
GEKPYECSECEKTFFCQSALNVHRRSHTGEKPYECSQCGKFLCTKSALIA
HQITHRGKKSYECNECGKFFCHKSTLTIHQRTHTGEKHGVFNKCGRISIV
KSNCSQCKRMNTKENLYECSEHGHAVSKNSHLIVHQRTIWERPYECNECG
RTYCRKSALTHHQRTHTGQRPYECNECGKTFCQKFSFVEHQRTHTGEKPY
ECNECGKSFCHKSAFRVHRRIHTGEKPYECNQCGKTYRRLWTLTEHQKIH
TGEKPYECNKCEKTFRHKSNFLLHQKSHKE

Funkcija

Ovaj gen kodira člana porodice C2H2 cinkovih prstiju. Kodirani protein sadrži Kueppel-povezani boks, četrnaest domena C2H2 cinkovog prsta i četiri domena vezivanja DNK tipa C2H2/integraza. Smanjena ekspresija ovog gena može biti marker za reumatoidni artritis. Alternativna prerada rezultira u više varijanti transkripta koji kodiraju različite proteinske izoforme.</ref name="entrez">

Reference

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017667 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Zinc finger protein 334". Pristupljeno 10. 3. 2016.

Dopunska literatura

  • Henc I, Soroczyńska-Cybula M, Bryl E, Witkowski JM (2015). "The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people". Acta Biochim. Pol. 62 (1): 113–7. doi:10.18388/abp.2014_857. PMID 25738173.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.