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ZNF277P
Identifikatori
Aliasi	ZNF277
Vanjski ID-jevi	OMIM: 605465 MGI: 1890393 HomoloGene: 11087 GeneCards: ZNF277
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	112,343,934 bp
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	40,495,901 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro;
Biološki proces	• regulation of cellular senescence; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • cellular response to hydrogen peroxide; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	11179
	246196
	ENSG00000198839
	ENSMUSG00000055917
	Q9NRM2
	E9Q6D6
	NM_021994
	NM_172575; NM_178845
	NP_068834
	NP_766163; NP_849173
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta 277 jest protein koji je kod ljudi kodiran genom ZNF277.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 450 aminokiselina, а molekulska težina Da. 52 788^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAASKTQGAV	ARMQEDRDGS	CSTVGGVGYG	DSKDCILEPL	SLPESPGGTT
TLEGSPSVPC	IFCEEHFPVA	EQDKLLKHMI	IEHKIVIADV	KLVADFQRYI
LYWRKRFTEQ	PITDFCSVIR	INSTAPFEEQ	ENYFLLCDVL	PEDRILREEL
QKQRLREILE	QQQQERNDTN	FHGVCMFCNE	EFLGNRSVIL	NHMAREHAFN
IGLPDNIVNC	NEFLCTLQKK	LDNLQCLYCE	KTFRDKNTLK	DHMRKKQHRK
INPKNREYDR	FYVINYLELG	KSWEEVQLED	DRELLDHQED	DWSDWEEHPA
SAVCLFCEKQ	AETIEKLYVH	MEDAHEFDLL	KIKSELGLNF	YQQVKLVNFI
RRQVHQCRCY	GCHVKFKSKA	DLRTHMEETK	HTSLLPDRKT	WDQLEYYFPT
YENDTLLCTL	SDSESDLTAQ	EQNENVPIIS	EDTSKLYALK	QSSILNQLLL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198839 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055917 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.
^ Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364.
^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.
^ "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".
^ "UniProt, Q9NRM2" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

Kumar S; Connor JR; Dodds RA; et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Ewing RM; Chu P; Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198839 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055917 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10860669-5] Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.

[pmid16213364-6] Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364.

[pmid16395595-7] Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.

[entrez-8] "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".

[UniProt-9] "UniProt, Q9NRM2" (jezik: engleski). Pristupljeno 29. 9. 2021.

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ZNF277P

Aminokiselinska sekvenca

Reference

Dopunska literatura

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