ZNF142

ZNF142
Identifikatori
AliasiZNF142
Vanjski ID-jeviOMIM: 604083 MGI: 1924514 HomoloGene: 3723 GeneCards: ZNF142
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za ZNF142
Genomska lokacija za ZNF142
Bend2q35Početak218,633,329 bp[1]
Kraj218,659,655 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za ZNF142
Genomska lokacija za ZNF142
Bend1 C4|1 38.54 cMPočetak74,604,286 bp[2]
Kraj74,627,405 bp[2]
Ontologija gena
Molekularna funkcija• vezivanje sa DNK
• vezivanje iona metala
• nucleic acid binding
• molekularna funkcija
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta• jedro
• ćelijska komponenta
Biološki proces• GO:0009373 regulation of transcription, DNA-templated
• transcription, DNA-templated
• GO:0022610 biološki proces
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

7701

77264

Ensembl

ENSG00000115568

ENSMUSG00000026135

UniProt

P52746

G5E869

RefSeq (mRNK)
NM_001105537
NM_001366287
NM_001366288
NM_001366289
NM_001366290

NM_001366291
NM_001367339
NM_001367340
NM_001367341
NM_001367342
NM_001379659
NM_001379660
NM_001379661
NM_001379662

NM_029888
NM_001310668

RefSeq (bjelančevina)
NP_001099007
NP_001353216
NP_001353217
NP_001353218
NP_001353219

NP_001353220
NP_001354268
NP_001354269
NP_001354270
NP_001354271
NP_001366588
NP_001366589
NP_001366590
NP_001366591

NP_001297597
NP_084164

Lokacija (UCSC)Chr 2: 218.63 – 218.66 MbChr 1: 74.6 – 74.63 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein cinkovog prsta 142 jest protein koji je kod ljudi kodiran genom ZNF142 sa hromosoma 2.[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.687 aminokiselina, a molekulska težina 187.880 Da.[6].

1020304050
MTDPLLDSQPASSTGEMDGLCPELLLIPPPLSNRGILGPVQSPCPSRDPA
PIPTEPGCLLVEATATEEGPGNMEIIVETVAGTLTPGAPGETPAPKLPPG
EREPSQEAGTPLPGQETAEEENVEKEEKSDTQKDSQKAVDKGQGAQRLEG
DVVSGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFF
TSKSKLKTHLLRELGEKAHHCPLCHYSAVERNALNRHMASMHEDISNFYS
DTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLRCFQEGCSYAAPDR
KAFIKHLKETHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDF
ACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKI
HQCPECNFATAHKRVLIRHMLLHTGEKPHKCELCDFTCRDVSYLSKHMLT
HSNTKDYMCTECGYVTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRADQL
SSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTPAPLYPCHYCS
YQSRHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKRKAHGYVP
GDQAWQLRYASQEPEGAMQGPTPPPDSEPSNQLSARPEGPGHEPGTVVDP
SLDQALPEMSEEVNTGRQEGSEAPHGGDLGGSPSPAEVEEGSCTLHLEAL
GVELESVTEPPLEEVTETAPMEFRPLGLEGPDGLEGPELSSFEGIGTSDL
SAEENPLLEKPVSEPSTNPPSLEEAPNNWVGTFKTTPPAETAPLPPLPES
ESLLKALRRQDKEQAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKA
LNLHSRTGCQGRREPLLCPECGASFKQQRGLSTHLLKKCPVLLRKNKGLP
RPDSPIPLQPVLPGTQASEDTESGKPPPASQEAELLLPKDAPLELPREPE
ETEEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPTEAPKKHH
LDPVPPAGNSSPTEALKKHRFEQGKFHCNSCPFLCSRLSSITSHVAEGCR
GGRGGGGKRGTPQTQPDVSPLSNGDSAPPKNGSTESSSGDGDTVLVQKQK
GARFSCPTCPFSCQQERALRTHQIRGCPLEESGELHCSLCPFTAPAATAL
RLHQKRRHPTAAPARGPRPHLQCGDCGFTCKQSRCMQQHRRLKHEGVKPH
QCPFCDFSTTRRYRLEAHQSRHTGIGRIPCSSCPQTFGTNSKLRLHRLRV
HDKTPTHFCPLCDYSGYLRHDITRHVNSCHQGTPAFACSQCEAQFSSETA
LKQHALRRHPEPAQPAPGSPAETTEGPLHCSRCGLLCPSPASLRGHTRKQ
HPRLECGACQEAFPSRLALDEHRRQQHFSHRCQLCDFAARERVGLVKHYL
EQHEETSAAVAASDGDGDAGQPPLHCPFCDFTCRHQLVLDHHVKGHGGTR
LYKCTDCAYSTKNRQKITWHSRIHTGEKPYHCHLCPYACADPSRLKYHMR
IHKEERKYLCPECGYKCKWVNQLKYHMTKHTGLKPYQCPECEYCTNRADA
LRVHQETRHREARAFMCEQCGKAFKTRFLLRTHLRKHSEAKPYVCNVCHR
AFRWAAGLRHHALTHTDRHPFFCRLCNYKAKQKFQVVKHVRRHHPDQADP
NQGVGKDPTTPTVHLHDVQLEDPSPPAPAAPHTGPEG

Funkcija

Protein kodiran ovim genom pripada Krupelskoj porodici proteina C2H2 tipa cinkovih prstiju. Sadrži 31 cinkov prst tipa C2H2 i može biti uključen u regulaciju transkripcije. Za ovaj gen su pronađene alternativno prerađene varijante transkripta.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115568 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026135 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 142". Pristupljeno 30. 1. 2017.
  6. ^ "UniProt, P52746" (jezik: engleski). Pristupljeno 17. 11. 2021.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

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