YTHDC2

YTHDC2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2YU6

Identifikatori
AliasiYTHDC2
Vanjski ID-jeviOMIM: 616530 MGI: 2448561 HomoloGene: 11265 GeneCards: YTHDC2
EC broj3.6.4.13
Lokacija gena (čovjek)
Hromosom 5 (čovjek)
Hrom.Hromosom 5 (čovjek)[1]
Hromosom 5 (čovjek)
Genomska lokacija za YTHDC2
Genomska lokacija za YTHDC2
Bend5q22.2Početak113,513,694 bp[1]
Kraj113,595,285 bp[1]
Lokacija gena (miš)
Hromosom 18 (miš)
Hrom.Hromosom 18 (miš)[2]
Hromosom 18 (miš)
Genomska lokacija za YTHDC2
Genomska lokacija za YTHDC2
Bend18|18 B3Početak44,960,813 bp[2]
Kraj45,022,791 bp[2]
Ontologija gena
Molekularna funkcija• nucleotide binding
• GO:0001948, GO:0016582 vezivanje za proteine
• RNA polymerase binding
• ATP binding
• hydrolase activity
• GO:0008026 helicase activity
• nucleic acid binding
• ATP-dependent activity, acting on RNA
• vezivanje sa RNK
• N6-methyladenosine-containing RNA binding
• GO:0034459 3'-5' RNA helicase activity
Ćelijska komponenta• Endoplazmatski retikulum
• citoplazma
• jedro
• ribonucleoprotein granule
Biološki proces• response to tumor necrosis factor
• GO:0033168, GO:0036404, GO:1902360 RNA processing
• response to interleukin-1
• positive regulation by host of viral genome replication
• Spermatogeneza
• spermatid development
• Ćelijska diferencijacija
• Ovogeneza
• oocyte development
• GO:0007126 Mejoza
• germline cell cycle switching, mitotic to meiotic cell cycle
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

64848

240255

Ensembl

ENSG00000047188

ENSMUSG00000034653

UniProt

Q9H6S0

B2RR83

RefSeq (mRNK)

NM_022828
NM_001345975
NM_001345976

NM_001163013

RefSeq (bjelančevina)

NP_001332904
NP_001332905
NP_073739

NP_001156485

Lokacija (UCSC)Chr 5: 113.51 – 113.6 MbChr 18: 44.96 – 45.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 2 sa YTH domenom je protein koji je kod ljudi kodiran genom YTHDC2.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.430 aminokiselina, a molekulska težina 160.248 Da.[6]

1020304050
MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVN
IALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYL
TVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTER
GNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQE
EIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRR
LAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL
MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAA
LDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKE
KQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVF
SQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVD
YRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHF
GQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD
DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFA
DSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDV
VFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFR
LFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEP
PPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVV
LKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL
LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV
RARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKK
VRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIR
CCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTA
NLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDE
ATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK
SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQ
SSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRN
LEISQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSS
EIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQIS
RDGQELEPLVGEQLLQLWERLPLGEKNTTD

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047188 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034653 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: YTH domain containing 2".
  6. ^ "UniProt, Q9H6S0" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura

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