USP47
Ubikvitinska karboksil-terminalna hidrolaza 47 je enzim koji je kod ljudi kodiran genom USP47.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 1.375 aminokiselina, а molekulska težina 157.311 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVPGEENQLV | PKEDVFWRCR | QNIFDEMKKK | FLQIENAAEE | PRVLCIIQDT | ||||
| TNSKTVNERI | TLNLPASTPV | RKLFEDVANK | VGYINGTFDL | VWGNGINTAD | ||||
| MAPLDHTSDK | SLLDANFEPG | KKNFLHLTDK | DGEQPQILLE | DSSAGEDSVH | ||||
| DRFIGPLPRE | GSGGSTSDYV | SQSYSYSSIL | NKSETGYVGL | VNQAMTCYLN | ||||
| SLLQTLFMTP | EFRNALYKWE | FEESEEDPVT | SIPYQLQRLF | VLLQTSKKRA | ||||
| IETTDVTRSF | GWDSSEAWQQ | HDVQELCRVM | FDALEQKWKQ | TEQADLINEL | ||||
| YQGKLKDYVR | CLECGYEGWR | IDTYLDIPLV | IRPYGSSQAF | ASVEEALHAF | ||||
| IQPEILDGPN | QYFCERCKKK | CDARKGLRFL | HFPYLLTLQL | KRFDFDYTTM | ||||
| HRIKLNDRMT | FPEELDMSTF | IDVEDEKSPQ | TESCTDSGAE | NEGSCHSDQM | ||||
| SNDFSNDDGV | DEGICLETNS | GTEKISKSGL | EKNSLIYELF | SVMVHSGSAA | ||||
| GGHYYACIKS | FSDEQWYSFN | DQHVSRITQE | DIKKTHGGSS | GSRGYYSSAF | ||||
| ASSTNAYMLI | YRLKDPARNA | KFLEVDEYPE | HIKNLVQKER | ELEEQEKRQR | ||||
| EIERNTCKIK | LFCLHPTKQV | MMENKLEVHK | DKTLKEAVEM | AYKMMDLEEV | ||||
| IPLDCCRLVK | YDEFHDYLER | SYEGEEDTPM | GLLLGGVKST | YMFDLLLETR | ||||
| KPDQVFQSYK | PGEVMVKVHV | VDLKAESVAA | PITVRAYLNQ | TVTEFKQLIS | ||||
| KAIHLPAETM | RIVLERCYND | LRLLSVSSKT | LKAEGFFRSN | KVFVESSETL | ||||
| DYQMAFADSH | LWKLLDRHAN | TIRLFVLLPE | QSPVSYSKRT | AYQKAGGDSG | ||||
| NVDDDCERVK | GPVGSLKSVE | AILEESTEKL | KSLSLQQQQD | GDNGDSSKST | ||||
| ETSDFENIES | PLNERDSSAS | VDNRELEQHI | QTSDPENFQS | EERSDSDVNN | ||||
| DRSTSSVDSD | ILSSSHSSDT | LCNADNAQIP | LANGLDSHSI | TSSRRTKANE | ||||
| GKKETWDTAE | EDSGTDSEYD | ESGKSRGEMQ | YMYFKAEPYA | ADEGSGEGHK | ||||
| WLMVHVDKRI | TLAAFKQHLE | PFVGVLSSHF | KVFRVYASNQ | EFESVRLNET | ||||
| LSSFSDDNKI | TIRLGRALKK | GEYRVKVYQL | LVNEQEPCKF | LLDAVFAKGM | ||||
| TVRQSKEELI | PQLREQCGLE | LSIDRFRLRK | KTWKNPGTVF | LDYHIYEEDI | ||||
| NISSNWEVFL | EVLDGVEKMK | SMSQLAVLSR | RWKPSEMKLD | PFQEVVLESS | ||||
| SVDELREKLS | EISGIPLDDI | EFAKGRGTFP | CDISVLDIHQ | DLDWNPKVST | ||||
| LNVWPLYICD | DGAVIFYRDK | TEELMELTDE | QRNELMKKES | SRLQKTGHRV | ||||
| TYSPRKEKAL | KIYLDGAPNK | DLTQD |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170242 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059263 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
- ^ "Entrez Gene: USP47 ubiquitin specific peptidase 47".
- ^ "UniProt, Q96K76". Pristupljeno 29. 8. 2021.
Dopunska literatura
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
- Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Vanjski linkovi
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