TRIL

TRIL
Identifikatori
AliasiTRIL
Vanjski ID-jeviOMIM: 613356 MGI: 1914123 HomoloGene: 69404 GeneCards: TRIL
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za TRIL
Genomska lokacija za TRIL
Bend7p14.3Početak28,953,358 bp[1]
Kraj28,958,330 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za TRIL
Genomska lokacija za TRIL
Bend6|6 B3Početak53,792,453 bp[2]
Kraj53,797,815 bp[2]
Ontologija gena
Molekularna funkcija• lipopolysaccharide binding
Ćelijska komponenta• integral component of membrane
• lipopolysaccharide receptor complex
• membrana
• Vanćelijsko
• GO:0005578 Vanćelijski matriks
Biološki proces• regulation of cytokine production involved in immune response
• Urođeni imunski sistem
• inflammatory response
• toll-like receptor 4 signaling pathway
• immune system process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

9865

66873

Ensembl

ENSG00000255690

ENSMUSG00000043496

UniProt

Q7L0X0

Q9DBY4

RefSeq (mRNK)

NM_014817

NM_025817

RefSeq (bjelančevina)

NP_055632

NP_080093

Lokacija (UCSC)Chr 7: 28.95 – 28.96 MbChr 6: 53.79 – 53.8 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

KIAA0644, znan i kao TRIL ili interaktor TLR4 sa leucinski bogatim ponavljanjima, jest protein koji je kod ljudi kodiran genom KIAA0644.[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 811 aminokiselina, а molekulska težina 88.723 Da.[6] Sastoji se prvenstveno od ostataka leucina (17%), alanina i arginina (~ 10%) i glicina (~ 8,5%). Predviđa se da se proteinska sekvenca sastoji uglavnom od α-heliksa i nekoliko β-listova

1020304050
MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVP
KTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHP
KTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGS
FEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFA
QLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQ
HLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL
HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA
LYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKY
LDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEEL
PPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAA
AAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRA
TKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSA
SVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRE
LRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTL
ALLTVNALLVLLALAAWASRWLRRKLRARRKGGAPVHVRHMYSTRRPLRS
MGTGVSADFSGFQSHRPRTTVCALSEADLIEFPCDRFMDSAGGGAGGSLR
REDRLLQRFAD

Gensko susjedstvo

Gen KIAA0644 susjedi je sa genom za vezanje elemenata koji reagiraju na iRNK–cAMP nizvodno i genom za karboksipeptidaznu iRNK i serin-karboksipeptidazu uzvodno.[7][8]

Funkcija

Tačna funkcija KIAA0644 nije poznata. Međutim, član je porodice proteina leucinom bogatog ponavljanja, za koje je poznato da su uključeni u interakcije protein-protein. Poznato je da ovaj protein stupa u interakciju s proteinom TLR4.

TRIL je komponenta kompleksa TLR4 i u brojnim tipovima ćelija induciran je lipopolisaharidom (LPS).[9]

Homologija

KIAA0644 dobro je konzerviran među sisarima, ali se može naći u svim hordatima s nižim identitetom sekvence.

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255690 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043496 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TRIL TLR4 interactor with leucine rich repeats". Pristupljeno 13. 5. 2010.
  6. ^ "UniProt, Q7L0X0" (jezik: engleski). Pristupljeno 29. 9. 2021.
  7. ^ "NCBI Entrez". Pristupljeno 13. 5. 2010.
  8. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (juni 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
  9. ^ Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (septembar 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–3995. doi:10.4049/jimmunol.0901518. PMID 19710467.

Dopunska literatura

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