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TNIP2
Identifikatori
Aliasi	TNIP2
Vanjski ID-jevi	OMIM: 610669 MGI: 2386643 HomoloGene: 11515 GeneCards: TNIP2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	2,756,342 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	34,671,335 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • protein kinase binding; • vezivanje iona metala; • polyubiquitin modification-dependent protein binding; • K63-linked polyubiquitin modification-dependent protein binding;
Ćelijska komponenta	• jedro; • citosol; • citoplazma; • nukleoplazma;
Biološki proces	• negative regulation of endothelial cell apoptotic process; • GO:0009373 regulation of transcription, DNA-templated; • CD40 signaling pathway; • protein stabilization; • positive regulation of macrophage activation; • transcription, DNA-templated; • stress-activated MAPK cascade; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of B cell activation; • inflammatory response; • I-kappaB kinase/NF-kappaB signaling; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0097285 apoptoza; • toll-like receptor 9 signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • protein deubiquitination; • cellular response to lipopolysaccharide; • interleukin-1-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	79155
	231130
	ENSG00000168884
	ENSMUSG00000059866
	Q8NFZ5
	Q99JG7
	NM_024309; NM_001161527; NM_001292016
	NM_139064
	NP_001154999; NP_001278945; NP_077285
	NP_620703
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TNFAIP3-interaktivirajući protein 2 jest protein koji je kod ljudi kodiran genom TNIP2 sa hromosoma 4.^[5]^[6]^[7] TNIP2 sadrži višestruka aminokiselinska mjesta koja su fosforilirana i ubikvitinirana.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 429 aminokiselina, а molekulska težina 48.700 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSRDPGSGGW	EEAPRAAAAL	CTLYHEAGQR	LRRLQDQLAA	RDALIARLRA
RLAALEGDAA	PSLVDALLEQ	VARFREQLRR	QEGGAAEAQM	RQEIERLTER
LEEKEREMQQ	LLSQPQHERE	KEVVLLRRSM	AEGERARAAS	DVLCRSLANE
THQLRRTLTA	TAHMCQHLAK	CLDERQHAQR	NVGERSPDQS	EHTDGHTSVQ
SVIEKLQEEN	RLLKQKVTHV	EDLNAKWQRY	NASRDEYVRG	LHAQLRGLQI
PHEPELMRKE	ISRLNRQLEE	KINDCAEVKQ	ELAASRTARD	AALERVQMLE
QQILAYKDDF	MSERADRERA	QSRIQELEEK	VASLLHQVSW	RQDSREPDAG
RIHAGSKTAK	YLAADALELM	VPGGWRPGTG	SQQPEPPAEG	GHPGAAQRGQ
GDLQCPHCLQ	CFSDEQGEEL	LRHVAECCQ

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168884 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059866 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
^ Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.
^ "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".
^ "TNIP2 (human)". www.phosphosite.org. Pristupljeno 31. 10. 2020.
^ "UniProt, Q8NFZ5" (jezik: engleski). Pristupljeno 31. 10. 2017.

Dopunska literatura

Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC 2133159. PMID 10385526.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905. S2CID 32414520.
Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760. S2CID 202644741.
Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. PMID 12609966.
Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905. S2CID 31400521.
Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. doi:10.1269/jrr.0615. PMID 17038805.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168884 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059866 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11390377-5] Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.

[pmid12933576-6] Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.

[entrez-7] "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".

[8] "TNIP2 (human)". www.phosphosite.org. Pristupljeno 31. 10. 2020.

[UniProt-9] "UniProt, Q8NFZ5" (jezik: engleski). Pristupljeno 31. 10. 2017.

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TNIP2

Aminokiselinska sekvenca

Reference

Dopunska literatura

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