THYN1

THYN1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3EOP, 5J3E

Identifikatori
AliasiTHYN1
Vanjski ID-jeviOMIM: 613739 MGI: 1925112 HomoloGene: 8575 GeneCards: THYN1
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za THYN1
Genomska lokacija za THYN1
Bend11q25Početak134,248,279 bp[1]
Kraj134,253,370 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za THYN1
Genomska lokacija za THYN1
Bend9|9 A4Početak26,911,006 bp[2]
Kraj26,918,632 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298

NM_144543
NM_001326361

RefSeq (bjelančevina)

NP_001032381
NP_001032382
NP_054893
NP_954994
NP_954995

NP_001313290
NP_653126

Lokacija (UCSC)Chr 11: 134.25 – 134.25 MbChr 9: 26.91 – 26.92 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Timocitni jedarni protein 1 je protein koji je kod ljudi kodiran genom THYN1.[5][6][7]

Ovaj gen kodira protein koji je visoko konzerviran među kičmenjacima i biljnim vrstama i može biti uključen u indukciju apoptoze. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 225 aminokiselina, а molekulska težina 25.697 Da.[8]

1020304050
MSRPRKRLAGTSGSDKGLSGKRTKTENSGEALAKVEDSNPQKTSATKNCL
KNLSSHWLMKSEPESRLEKGVDVKFSIEDLKAQPKQTTCWDGVRNYQARN
FLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAYPDHTQFEKNNPHYDPS
SKEDNPKWSMVDVQFVRMMKRFIPLAELKSYHQAHKATGGPLKNMVLFTR
QRLSIQPLTQEEFDFVLSLEEKEPS

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151500 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035443 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID 14601557. S2CID 2092518.
  6. ^ Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID 12384300.
  7. ^ a b "Entrez Gene: THYN1 thymocyte nuclear protein 1".
  8. ^ "UniProt, Q9P016". Pristupljeno 28. 8. 2021.

Dopunska literatura

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