SYCP1
Sinaptonemski kompleksni protein 1 jest protein koji je kod ljudi kodiran genom SYCP1 sa hromosoma 1. Uključen je u sinaptonemski kompleks tokom mejoze.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 976 aminokiselina, a molekulska težina 114.192 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MEKQKPFALF | VPPRSSSSQV | SAVKPQTLGG | DSTFFKSFNK | CTEDDFEFPF | ||||
| AKTNLSKNGE | NIDSDPALQK | VNFLPVLEQV | GNSDCHYQEG | LKDSDLENSE | ||||
| GLSRVYSKLY | KEAEKIKKWK | VSTEAELRQK | ESKLQENRKI | IEAQRKAIQE | ||||
| LQFGNEKVSL | KLEEGIQENK | DLIKENNATR | HLCNLLKETC | ARSAEKTKKY | ||||
| EYEREETRQV | YMDLNNNIEK | MITAFEELRV | QAENSRLEMH | FKLKEDYEKI | ||||
| QHLEQEYKKE | INDKEKQVSL | LLIQITEKEN | KMKDLTFLLE | ESRDKVNQLE | ||||
| EKTKLQSENL | KQSIEKQHHL | TKELEDIKVS | LQRSVSTQKA | LEEDLQIATK | ||||
| TICQLTEEKE | TQMEESNKAR | AAHSFVVTEF | ETTVCSLEEL | LRTEQQRLEK | ||||
| NEDQLKILTM | ELQKKSSELE | EMTKLTNNKE | VELEELKKVL | GEKETLLYEN | ||||
| KQFEKIAEEL | KGTEQELIGL | LQAREKEVHD | LEIQLTAITT | SEQYYSKEVK | ||||
| DLKTELENEK | LKNTELTSHC | NKLSLENKEL | TQETSDMTLE | LKNQQEDINN | ||||
| NKKQEERMLK | QIENLQETET | QLRNELEYVR | EELKQKRDEV | KCKLDKSEEN | ||||
| CNNLRKQVEN | KNKYIEELQQ | ENKALKKKGT | AESKQLNVYE | IKVNKLELEL | ||||
| ESAKQKFGEI | TDTYQKEIED | KKISEENLLE | EVEKAKVIAD | EAVKLQKEID | ||||
| KRCQHKIAEM | VALMEKHKHQ | YDKIIEERDS | ELGLYKSKEQ | EQSSLRASLE | ||||
| IELSNLKAEL | LSVKKQLEIE | REEKEKLKRE | AKENTATLKE | KKDKKTQTFL | ||||
| LETPEIYWKL | DSKAVPSQTV | SRNFTSVDHG | ISKDKRDYLW | TSAKNTLSTP | ||||
| LPKAYTVKTP | TKPKLQQREN | LNIPIEESKK | KRKMAFEFDI | NSDSSETTDL | ||||
| LSMVSEEETL | KTLYRNNNPP | ASHLCVKTPK | KAPSSLTTPG | STLKFGAIRK | ||||
| MREDRWAVIA | KMDRKKKLKE | AEKLFV |
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198765 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027855 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (Jun 1998). "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens". Proc Natl Acad Sci U S A. 95 (9): 5211–6. Bibcode:1998PNAS...95.5211T. doi:10.1073/pnas.95.9.5211. PMC 20240. PMID 9560255.
- ^ "Entrez Gene: SYCP1 synaptonemal complex protein 1".
- ^ "UniProt, Q15431" (jezik: eng.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dolpunska literatura
- Neumann F, Wagner C, Preuss KD, et al. (2005). "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells". Blood. 106 (9): 3105–13. doi:10.1182/blood-2005-04-1487. PMID 16030183.
- Costa Y, Speed R, Ollinger R, et al. (2005). "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis". J. Cell Sci. 118 (Pt 12): 2755–62. doi:10.1242/jcs.02402. PMID 15944401.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
- Kondoh N, Nishina Y, Tsuchida J, et al. (1997). "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis". Cytogenet. Cell Genet. 78 (2): 103–4. doi:10.1159/000134637. PMID 9371398.
- Meuwissen RL, Meerts I, Hoovers JM, et al. (1997). "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene" (PDF). Genomics. 39 (3): 377–84. doi:10.1006/geno.1996.4373. PMID 9119375.
- Meuwissen RL, Offenberg HH, Dietrich AJ, et al. (1993). "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes". EMBO J. 11 (13): 5091–100. doi:10.1002/j.1460-2075.1992.tb05616.x. PMC 556987. PMID 1464329.
Vanjski linkovi
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.